Fmoc-D-proline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 101555-62-8 |
| Product name | Fmoc-D-proline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-D-proline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-D-proline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-D-proline
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a chiral building block in solid-phase synthesis of peptide-based drugs (e.g., antitumor agents, hormone analogs) | Applied as an amino acid derivative in SPPS (solid-phase peptide synthesis), with chain elongation enabled by base-labile deprotection of the Fmoc protecting group |
| Biochemistry | Used to prepare custom peptides with defined secondary structures (e.g., proline-induced β-turns) | Employed in stepwise coupling on automated peptide synthesizers, followed by cleavage from resin and purification via acidolysis |
| Academic Research | Used as a chiral catalyst or intermediate in asymmetric organic synthesis studies | Applied as a building block in solution-phase reactions, participating in carbon–carbon bond formation or cyclization reactions |
| Diagnostics Reagents | Used to synthesize labeled peptide probes (e.g., fluorescently tagged targeting peptides) | Conjugated with other functionalized amino acids via Fmoc chemistry to produce bioconjugates |
Manufacturing Quality Control of Fmoc-D-proline
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a certified reference standard using reversed-phase chromatography and UV detection at 268 nm. |
| Chiral Purity | Chiral HPLC | Separation of D- and L-enantiomers on a chiral stationary phase with UV detection; enantiomeric excess calculated from peak areas. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine-based reagent to quantify water content based on stoichiometric reaction. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to identify and quantify volatile organic solvents (e.g., DMF, THF, ethyl acetate). |
| Heavy Metals | ICP-OES | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion and plasma excitation. |
| Residue on Ignition | Gravimetric Analysis | Measurement of inorganic ash content after high-temperature incineration at 700-800 C. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light induced by chiral molecules in solution at specified concentration and wavelength. |
| pH (1% aqueous solution) | Potentiometric pH Measurement | Determination of hydrogen ion activity using calibrated glass electrode in aqueous suspension. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., Fmoc-proline, D-proline, dipeptide by-products) using gradient RP-HPLC. |
| Appearance | Visual Inspection | Assessment of physical state, color, and homogeneity under controlled lighting against defined standards. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size by measuring angular variation in laser light scattering. |
| Microbial Contamination | Membrane Filtration | Enumeration of aerobic microorganisms via filtration, membrane transfer to culture media, and colony counting after incubation. |
Technical Specifications of Fmoc-D-proline
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 128.0 to 132.0 °C |
| Optical Rotation | +30.0 to +34.0 (c=1, in DMF) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-D-proline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-D-proline
Packaging of Fmoc-D-proline
Industrial Fmoc-D-proline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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