(S)-Tert-butyl (piperidin-3-ylmethyl)carbamate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1016167-99-9 |
| Product name | (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral intermediate for synthesizing CNS therapeutics, including selective 5-HT1F receptor agonists (e.g., lasmiditan) | BOC deprotection prior to coupling reactions, generating free amine for subsequent amidation or reductive amination steps |
| Pharmaceutical R&D | Chiral amine building block containing a 3-piperidinyl moiety, used in structural optimization of migraine, antidepressant, and analgesic candidate compounds | Used as a chiral synthon in multi-step total synthesis, typically introduced into the target molecular scaffold via palladium-catalyzed cross-coupling or stereoselective alkylation |
| Fine Chemicals | High-purity chiral building block supplied to CRO/CDMO companies for custom synthesis services | Purified by recrystallization or preparative chiral HPLC, then supplied directly to downstream customers for drug process route development and validation |
Manufacturing Quality Control of (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210 nm based on peak area comparison against reference standard. |
| Enantiomeric Excess (ee) | Chiral HPLC | Measures enantiomeric purity by separating (R)- and (S)-enantiomers on a chiral stationary phase and calculating ee from peak areas. |
| Residual Solvents | GC-FID | Detects and quantifies common organic solvents (e.g., MeOH, EtOAc, THF) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines water content via coulometric or volumetric titration using iodine generated electrochemically in presence of water. |
| Heavy Metals | ICP-MS | Quantifies trace heavy metals (e.g., Pb, Cd, Ni, Pd) after acid digestion using inductively coupled plasma mass spectrometry. |
| Residual Palladium | ICP-OES | Measures residual palladium from catalytic synthesis steps by atomic emission detection after microwave-assisted acid digestion. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column with suppressed conductivity detection. |
| Related Substances | HPLC-UV | Identifies and quantifies structurally related impurities (e.g., deprotected amine, BOC-hydrolysis products) using gradient HPLC-UV. |
| Appearance | Visual Inspection | Assesses physical state, color, and clarity of solid sample against established visual standards under controlled lighting. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid using calibrated capillary apparatus per USP <741>. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic residue remaining after high-temperature ashing (600-800 C) followed by precise weighing. |
| Specific Optical Rotation | Polarimetry | Measures angle of rotation of plane-polarized light induced by chiral compound in solution at specified concentration and wavelength (e.g., 589 nm). |
Technical Specifications of (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 78–82°C |
| Optical Rotation | +15.0 to +17.0° (c=1, in methanol) |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate
Safety Information of (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate
Industrial (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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