N-Boc-cis-4-Hydroxy-L-proline methyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 102195-79-9 |
| Product name | N-Boc-cis-4-Hydroxy-L-proline methyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Boc-cis-4-Hydroxy-L-proline methyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Boc-cis-4-Hydroxy-L-proline methyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Boc-cis-4-Hydroxy-L-proline methyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral synthetic intermediate for constructing peptide-based therapeutics containing the cis-4-hydroxyproline motif (e.g., antifibrotic and antiviral candidate compounds) | Chirality-directed solid-phase or solution-phase peptide coupling; Boc deprotection under mild acidic conditions (e.g., TFA/DCM), followed by subsequent functionalization |
| Innovative Drug CDMO | Critical chiral building block for synthesizing small-molecule inhibitors targeting collagenase or prolyl hydroxylase | Multi-step transformations including ester hydrolysis, selective hydroxyl protection/derivatization, and amine coupling; commonly employed as a C4-hydroxy stereospecific installation unit |
| Biobiochemical Research | Conformationally constrained amino acid derivative for preparing structural probes and protein–protein interaction inhibitors | Coupling into peptide chains using activated carboxylic acids (e.g., HATU/DIPEA); the cis-hydroxy configuration—confirmed by X-ray crystallography—is critical for target binding |
Manufacturing Quality Control of N-Boc-cis-4-Hydroxy-L-proline methyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification via reverse-phase HPLC with UV detection at 210 nm, using external standard calibration. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase, with UV detection to determine enantiomeric excess. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Coulometric or volumetric titration with iodine-based reagent to determine trace water content. |
| Heavy Metals | ICP-OES | Multi-element detection of Pb, Cd, Hg, As, and other heavy metals after acid digestion and plasma excitation. |
| Residual Palladium | ICP-MS | Ultra-trace quantification of palladium catalyst residues using inductively coupled plasma mass spectrometry. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities using gradient reverse-phase HPLC. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid transition temperature range using calibrated capillary apparatus. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light to confirm stereochemical integrity. |
| Residual Chlorides | Ion Chromatography | Quantification of chloride ions via suppressed conductivity detection after anion exchange separation. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size by measuring angular scattering pattern of laser beam. |
| Microbial Limits | Membrane Filtration / Plate Count | Enumeration of aerobic microorganisms using membrane filtration followed by incubation on TSA agar. |
Technical Specifications of N-Boc-cis-4-Hydroxy-L-proline methyl ester
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -66° to -62° (c=1, in methanol) |
| Melting Point | 118°C to 122°C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Boc-cis-4-Hydroxy-L-proline methyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Boc-cis-4-Hydroxy-L-proline methyl ester
Safety Information of N-Boc-cis-4-Hydroxy-L-proline methyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N-Boc-cis-4-Hydroxy-L-proline methyl ester
Industrial N-Boc-cis-4-Hydroxy-L-proline methyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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