4-Methylsulphonylacetophenone Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 10297-73-1 |
| Product name | 4-Methylsulphonylacetophenone |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Methylsulphonylacetophenone
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Methylsulphonylacetophenone Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Methylsulphonylacetophenone
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of nonsteroidal anti-inflammatory drugs (e.g., Rofecoxib, Nepafenac) | Introduced via Friedel–Crafts acylation or other condensation reactions |
| Pharmaceuticals | Preparation of drug molecules with antibacterial and anti-inflammatory activity | Used as a synthetic building block to construct drug scaffolds |
| Chemicals | Organic synthesis raw material or building block | Applied in the preparation of sulfone derivatives or as a reaction substrate |
| Chemicals | Medicinal chemistry research | Employed in the development of novel drug compounds or synthetic route studies |
Manufacturing Quality Control of 4-Methylsulphonylacetophenone
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities (e.g., 4-(methylsulfonyl)benzaldehyde, desulfonylated byproducts) using gradient HPLC-UV against reference standards or threshold-based area normalization. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify residual solvents (e.g., acetone, methanol, ethyl acetate) per ICH Q3C guidelines. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion, achieving sub-ppb sensitivity and compliance with ICH Q3D. |
| Moisture Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water content via iodine generation and stoichiometric reaction with water in anhydrous medium. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition detection by observing solid-to-liquid phase change under controlled heating rate per USP <741>. |
| Sulfone Group Integrity | FT-IR Spectroscopy | Identification and verification of characteristic S=O stretching vibrations (~1310 cm⁻¹ and ~1150 cm⁻¹) and aromatic C–H modes for structural confirmation. |
| Chloride Impurity | Ion Chromatography (IC) | Anion-exchange chromatography with conductivity detection to quantify chloride ions arising from synthesis or handling. |
| Appearance & Color | Visual Inspection / Hazen (APHA) Scale | Subjective visual assessment against water standard; color intensity measured spectrophotometrically per ASTM D1209. |
| Bulk Density | USP <616> Tap Density Method | Determination of tapped density using standardized mechanical tapping of a known powder mass in a calibrated cylinder. |
| Particle Size Distribution | Laser Diffraction | Analysis of particle size distribution in dry dispersion mode, reporting D10, D50, D90 values per ISO 13320. |
| Residue on Ignition | Gravimetric Analysis (Weight Loss on Ignition) | Measurement of inorganic residue after controlled ashing at 700–800 °C, indicating non-volatile inorganic contaminants. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light to assess chiral purity (if applicable; compound is achiral, but used to confirm absence of optically active contaminants). |
Technical Specifications of 4-Methylsulphonylacetophenone
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (GC) |
| Melting Point | 78-82°C |
| Total Impurities | <=2.0% (GC) |
| Single Impurity | <=0.5% (GC) |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Methylsulphonylacetophenone
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Methylsulphonylacetophenone
Safety Information of 4-Methylsulphonylacetophenone
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Methylsulphonylacetophenone
Industrial 4-Methylsulphonylacetophenone Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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