Fmoc-N-methyl-D-leucine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 103478-63-3 |
| Product name | Fmoc-N-methyl-D-leucine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-N-methyl-D-leucine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-N-methyl-D-leucine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-N-methyl-D-leucine
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Chiral protected amino acid monomers for solid-phase peptide synthesis | Used as an N-terminal D-leucine derivative in Fmoc-based strategies to introduce methylated side chains and control stereochemistry during synthesis of antitumor peptides, cyclic peptides, and targeted probes |
| Drug Discovery | Structural modification unit for novel proteolysis-targeting chimeras (PROTACs) and peptide-based therapeutics | Coupled to E3 ligase ligands or target protein ligand fragments during solid-phase synthesis to modulate binding affinity and metabolic stability via steric effects |
| Chemical Biology | Chemical probe construction for studying post-translational modifications (e.g., methylation) | Applied as a structural module containing N-methyl-D-amino acids to synthesize mimetic peptide probes with enhanced membrane permeability and protease resistance |
Manufacturing Quality Control of Fmoc-N-methyl-D-leucine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component by UV absorption at 268 nm using reverse-phase C18 column and gradient elution with acetonitrile/water containing TFA. |
| Chiral Purity | Chiral HPLC | Resolves enantiomers using chiral stationary phase (e.g., Chirobiotic T) and detects D- vs L-isomer ratio via UV. |
| Water Content | Karl Fischer Titration | Measures trace water by coulometric or volumetric titration with iodine generation in pyridine/methanol solvent system. |
| Residual Solvents | GC-FID | Detects and quantifies residual solvents (e.g., DMF, DCM, MeOH) using capillary column and flame ionization detection. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (Pb, Cd, As, Hg, etc.) after acid digestion by mass spectrometric detection of isotopic signals. |
| Residual Chloride | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column and suppressed conductivity detection. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of visible particulates or clumps against white/black background under controlled lighting. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated digital melting point instrument. |
| Specific Optical Rotation | Polarimetry | Measures angle of rotation of plane-polarized light in solution to confirm chiral integrity and concentration. |
| Related Substances | HPLC-UV | Identifies and quantifies structurally related impurities (e.g., Fmoc-Leu, N-methyl-D-leucine, dipeptide by-products) using validated gradient method. |
| Loss on Drying | Gravimetric Analysis | Determines volatile content by measuring weight loss after drying under specified vacuum/temperature conditions. |
| pH of Solution | Potentiometric pH Measurement | Measures hydrogen ion activity in aqueous solution (1% w/v) using calibrated glass electrode and pH meter. |
Technical Specifications of Fmoc-N-methyl-D-leucine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | +15.5 to +20.5 deg (c=1, DMF) |
| Melting Point | 78 to 82 °C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-N-methyl-D-leucine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-N-methyl-D-leucine
Packaging of Fmoc-N-methyl-D-leucine
Industrial Fmoc-N-methyl-D-leucine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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