tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1034975-35-3 |
| Product name | tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | As a pharmaceutical intermediate for synthesizing antipsychotic agents (e.g., precursor to lurasidone) | Used as a protecting group in organic synthesis; employed in amidation, coupling, and related reaction steps |
| Pharmaceutical R&D | For constructing piperazine-containing compound libraries | Key building block in high-throughput screening and structure–activity relationship (SAR) studies |
| Fine Chemicals | Supplied as a custom synthesis intermediate to pharmaceutical manufacturers | t-Butyl ester protection and deprotection in multistep synthetic routes |
Manufacturing Quality Control of tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component by retention time and UV absorbance relative to a certified reference standard. |
| Related Substances | HPLC-UV/DAD | Detects and quantifies structurally related impurities using gradient elution and diode-array detection. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., THF, DMF, toluene) via headspace injection and flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines trace water by coulometric or volumetric titration based on iodine-sulfur dioxide redox reaction. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni, Pd) after acid digestion using inductively coupled plasma mass spectrometry. |
| Chloride Content | Ion Chromatography (IC) | Separates and quantifies chloride ions using anion-exchange column and suppressed conductivity detection. |
| Residual Palladium | ICP-MS | Specific quantification of palladium catalyst residue via high-sensitivity mass detection after microwave digestion. |
| Optical Rotation | [α]D | Measures specific rotation using sodium D-line light to confirm chiral integrity and absence of racemization. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition as indicator of crystallinity and purity. |
| Particle Size Distribution | Laser Diffraction | Analyzes size distribution of solid particles in suspension using Mie scattering theory. |
| Bulk & Tapped Density | USP <616> | Measures mass per unit volume under standardized tapping and gravitational conditions to assess flowability and compressibility. |
| Microbial Limits | Membrane Filtration + Culture | Detects aerobic microorganisms and specified pathogens using filtration, incubation, and colony enumeration per pharmacopeial methods. |
| Residual tert-Butyl Alcohol | GC-FID | Quantifies residual t-BuOH (from incomplete deprotection or synthesis) via headspace GC with FID detection. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Evaluates surface acidity/basicity by measuring H⁺ activity in a defined aqueous slurry (e.g., 10% w/v). |
Technical Specifications of tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate
Safety Information of tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate
Industrial tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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