4-Methoxyphenylacetic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 104-01-8 |
| Product name | 4-Methoxyphenylacetic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Methoxyphenylacetic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Methoxyphenylacetic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Methoxyphenylacetic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Side-chain intermediate for synthesizing antibiotics such as amoxicillin | Precursor used to prepare the amoxicillin side chain (e.g., p-methoxyphenylglycine derivatives) via condensation with appropriate amino compounds |
| Pharmaceutical Industry | Synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics | Serves as the drug molecular scaffold; converted into anti-inflammatory and analgesic agents through functional group transformations (e.g., amidation, esterification) |
| Pharmaceutical Industry | Key intermediate for synthesizing the vasodilator cinnarizine (also known as cerebroxine) | Condenses with diphenylmethylpiperazine derivatives to construct the drug’s molecular structure |
| Organic Synthesis | Synthesis of p-methoxyacetophenone | Converted via decarboxylation or oxidation for use in fragrance and dye synthesis |
| Agrochemical Industry | Synthesis of plant growth regulators and agrochemical intermediates | Participates in esterification or amidation reactions to produce biologically active agrochemical compounds |
| Fragrance Industry | Synthesis of lilial and its derivatives | Prepared via asymmetric synthesis or reduction for formulating floral-type fragrances |
| Dye Industry | Production of dye intermediates | Serves as a precursor to diazo components or coupling components in azo dye synthesis |
Manufacturing Quality Control of 4-Methoxyphenylacetic acid
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Utilizes a reversed-phase C18 column with methanol-water or acetonitrile-water as the mobile phase, detected by UV detector (e.g., 254 nm). Content is calculated using external standard or internal standard method. This technique offers high sensitivity and reproducibility, making it the preferred method for quantitative analysis. |
| Purity Analysis | Gas Chromatography (GC) | After appropriate derivatization (e.g., esterification), capillary columns are used for separation, with flame ionization detection (FID) for analysis. Suitable for volatile impurities and residual solvent testing, commonly applied in purity assessment. |
| Impurity Analysis | HPLC-UV or HPLC-MS | Combines high-performance liquid chromatography with UV or mass spectrometry detection, enabling identification and quantification of structurally similar compounds and synthetic by-products. Particularly effective for simultaneous analysis of multiple impurities, offering high selectivity and qualitative capability. |
| Structure Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | ¹H NMR and ¹³C NMR provide detailed molecular structural information, confirming functional group positions and connectivity. Considered the gold standard for structure elucidation. |
| Functional Group Identification | Infrared Spectroscopy (IR) | Characterized absorption peaks (e.g., carboxyl O-H stretch at ~3000–2500 cm⁻¹, C=O carbonyl at ~1700 cm⁻¹, aromatic C-O ether at ~1250–1100 cm⁻¹) help determine the presence of specific functional groups, supporting structural verification. |
| Residual Solvent Testing | Gas Chromatography (GC-FID/MS) | Uses headspace injection or direct injection to detect organic solvents (e.g., ethanol, acetone, dichloromethane) potentially remaining from synthesis processes. Complies with ICH Q3C guidelines. |
| Melting Point Determination | Melting Point Instrument Method | Determined via differential scanning calorimetry (DSC) or capillary melting point apparatus. Provides a physical property indicator useful for preliminary assessment of purity and consistency. |
Technical Specifications of 4-Methoxyphenylacetic acid
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow crystalline powder |
| Purity | >=98.5% (by LC-MS) |
| Melting Point | 76–79 °C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
| Acid Value (mg KOH/g) | 340–360 mg KOH/g |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Methoxyphenylacetic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Methoxyphenylacetic acid
Packaging of 4-Methoxyphenylacetic acid
Industrial 4-Methoxyphenylacetic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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