4-Nitrophenylacetic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 104-03-0 |
| Product name | 4-Nitrophenylacetic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Nitrophenylacetic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Nitrophenylacetic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Nitrophenylacetic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of antibiotic and anti-inflammatory drug intermediates | Used as an organic synthesis intermediate for preparing p-aminophenylacetic acid–based drugs |
| Pesticides | Raw material for plant growth regulators and insecticides | Applied in the synthesis of biologically active pesticide compounds |
| Dyes | Intermediate for azo dyes | Used in diazotization reactions to prepare dye molecules with specific structures |
| Organic Synthesis | Synthesis of other nitroaromatic compounds | Converted into various derivatives via reduction, esterification, and related reactions |
Manufacturing Quality Control of 4-Nitrophenylacetic acid
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color and physical state (typically a white to pale crystalline powder) with the naked eye to determine if it meets the standard requirements. |
| Melting Point | Capillary Melting Point Determination | Fill the sample into a capillary tube, place it in a melting point apparatus or Thiele tube, and heat it. Record the temperature range from initial melting to complete melting. The standard melting point of p-nitrophenylacetic acid is approximately 125–127 °C. |
| Identification | Infrared Spectroscopy (IR) | Prepare the sample as a pellet (e.g., KBr pellet) and measure the infrared absorption spectrum. Compare the characteristic absorption peaks with the reference spectrum (e.g., nitro group —NO₂ at ~1520 cm⁻¹ and ~1340 cm⁻¹, carboxylic acid C=O at ~1700 cm⁻¹). |
| Identification | High-Performance Liquid Chromatography (HPLC) Retention Time Comparison | Under specific chromatographic conditions (e.g., C18 column, methanol-water or acetonitrile-water mobile phase), compare the retention time of the test sample with that of the reference standard to confirm identity. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use external standard method or internal standard method. Under optimized chromatographic conditions (e.g., UV detector, wavelength around 254 nm), determine the peak area of the main component and calculate the content of p-nitrophenylacetic acid, typically requiring ≥98.0% or according to pharmacopoeia specifications. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Use gradient or isocratic elution programs to separate and detect possible impurities (e.g., unreacted raw materials, by-products, degradation products). Control the limits of individual impurities and total impurities using area normalization or self-reference methods. |
| Drying Loss | Drying Loss Method | Take an appropriate amount of sample and dry it at 105 °C until constant weight. Calculate the loss on drying percentage to control moisture and volatile substances, typically with a limit ≤0.5%. |
| Residue on Ignition | Ignition Residue Determination | Ignite the sample at high temperature (approximately 700–800 °C) and weigh the residual inorganic matter. Control the content of inorganic impurities, typically with a limit ≤0.1%. |
| pH Value | pH Meter Measurement | Prepare a solution of a certain concentration (e.g., 1% aqueous solution or appropriate solvent system) and measure its pH value using a calibrated pH meter to assess the acidity level and ensure it meets requirements. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection GC to detect residual organic solvents (e.g., toluene, ethanol, dichloromethane) from the synthesis process. Control the limits according to ICH Q3C guidelines. |
Technical Specifications of 4-Nitrophenylacetic acid
| Test Item | Specification |
|---|---|
| Appearance | White to greenish-brown crystalline powder |
| Purity | >=98.0% (by LC-MS) |
| Melting Point | 148–152°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Nitrophenylacetic acid
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| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Nitrophenylacetic acid
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Industrial 4-Nitrophenylacetic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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