N,O-Bis(trimethylsilyl)acetamide Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 10416-59-8 |
| Product name | N,O-Bis(trimethylsilyl)acetamide |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Material GradeSpecialty GradeIndustrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N,O-Bis(trimethylsilyl)acetamide
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N,O-Bis(trimethylsilyl)acetamide Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N,O-Bis(trimethylsilyl)acetamide
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Used as an amidation/amino-protecting reagent for selective silylation protection of primary and secondary amines in peptide synthesis and active pharmaceutical ingredient (API) manufacturing | Reacted with amine substrates under anhydrous, inert atmosphere at room temperature or low temperature (0–25 °C) to form N-trimethylsilylated derivatives; deprotection is subsequently achieved via mild acid treatment (e.g., dilute hydrochloric acid or acetic acid) |
| Organic Synthesis | Employed as a weakly basic catalyst and trimethylsilylating agent to facilitate enol silyl ether preparation, α-functionalization of aldehydes and ketones, and Weinreb amide synthesis | Reacted with carbonyl compounds (e.g., aldehydes, ketones) in the presence of a catalytic amount of Lewis acid (e.g., TiCl₄), or directly with carboxylic acids or Weinreb amine precursors to generate O- or N-silylated intermediates |
| Materials Science | Utilized as a precursor in the synthesis of silicon-nitrogen-containing polymers or ceramic precursors to enhance thermal stability and film-forming properties | Thermally decomposed during high-temperature pyrolysis or sol-gel processing to release hexamethyldisilazane (HMDS), forming Si–N–C network structures |
Manufacturing Quality Control of N,O-Bis(trimethylsilyl)acetamide
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity | Gas Chromatography (GC) | Separation using a capillary column and quantification with an FID detector. Main component purity is calculated by peak area normalization or external standard method, while simultaneously detecting organic impurities. |
| Water Content | Karl Fischer Titration (KF) | Based on electrochemical titration principle, this method accurately measures trace amounts of moisture in samples, ensuring the reactivity of BSTFA as a derivatization reagent is not compromised. |
| Inorganic Impurities (e.g., chloride, sulfate) | Ion Chromatography (IC) | After appropriate sample pretreatment, anion exchange column separation is performed followed by conductometric detection for quantitative analysis of inorganic salt impurities. |
| Volatile Organic Impurities | Headspace Gas Chromatography-Mass Spectrometry (HS-GC/MS) | Headspace sampling avoids interference from high-boiling components; GC/MS is used for qualitative and quantitative analysis of residual solvents or low-boiling by-products such as hexamethyldisiloxane. |
| Appearance and Color | Visual Comparison (Colorimetry) | Observe color and clarity under standard lighting conditions. Typically requires a colorless, transparent liquid free of suspended particles or precipitates. |
| Density | Density Meter Method / Specific Gravity Bottle Method | Measure density at 20°C or 25°C to assist in assessing batch consistency and detecting potential adulteration or dilution. |
| Refractive Index | Abe Refractometer Method | Determine refractive index at 20°C or 25°C as a physical constant to verify product quality and consistency. |
| Acidity/Alkalinity (pH-related) | Non-aqueous Titration / pH Test Strips (approximate) | BSTFA is prone to hydrolysis upon contact with water; thus, non-aqueous titration (e.g., in isopropanol) with standard acid/base is used to determine free acid or base content, controlling hydrolysis by-product levels. |
| Derivatization Efficiency Testing | Standard Substance Derivatization + GC/MS Verification | Perform derivatization reactions using known concentrations of standard acids/alcohols (e.g., fatty acids, phenolic compounds), then evaluate reagent activity based on response intensity and reproducibility of the resulting product peaks via GC/MS. |
Technical Specifications of N,O-Bis(trimethylsilyl)acetamide
| Test Item | Specification |
|---|---|
| Appearance | Colorless to light yellow clear liquid |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Refractive Index (n20/D) | 1.425–1.435 |
| Odor | Characteristic, mild amide-like |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N,O-Bis(trimethylsilyl)acetamide
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N,O-Bis(trimethylsilyl)acetamide
Safety Information of N,O-Bis(trimethylsilyl)acetamide
| Pictograms |   |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of N,O-Bis(trimethylsilyl)acetamide
Industrial N,O-Bis(trimethylsilyl)acetamide Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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