2-Chloro-5-hydroxymethylp... Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1046816-75-4 |
| Product name | 2-Chloro-5-hydroxymethylp... |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Chloro-5-hydroxymethylp...
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Chloro-5-hydroxymethylp... Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Chloro-5-hydroxymethylp...
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Pharmaceutical Intermediates | Serves as a key structural unit in the synthesis of antitumor agents, including protein kinase inhibitors (e.g., EGFR and VEGFR inhibitors). |
| Pharmaceutical Chemicals | Synthesis of Pyrimidine Derivatives | Leverages the nucleophilic substitution reactivity of chloropyrimidine rings to construct complex drug molecules containing a pyrimidine scaffold. |
| Organic Synthesis | Alcohol Transformation Reactions | Converts the hydroxymethyl functional group via oxidation, esterification, or halogenation to produce corresponding pyrimidine aldehydes, esters, or halide derivatives. |
Manufacturing Quality Control of 2-Chloro-5-hydroxymethylp...
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 254 nm, comparing peak area to calibrated standard. |
| Related Substances | HPLC-UV | Detects and quantifies impurities by retention time and UV response relative to main peak using gradient elution. |
| Residual Solvents | GC-FID | Separates and quantifies volatile organic solvents (e.g., methanol, acetone) via capillary GC with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines water by coulometric or volumetric titration using iodine generation in pyridine-free reagent system. |
| Chloride Impurity | Ion Chromatography (IC) | Separates and quantifies chloride ions using anion-exchange column and conductivity detection. |
| Heavy Metals | ICP-MS | Measures trace metal elements (e.g., Pb, Cd, Ni) after acid digestion by inductively coupled plasma mass spectrometry. |
| Residue on Ignition | Gravimetric Analysis | Measures non-volatile inorganic residue after high-temperature ashing at 700-800 C and weighing. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using controlled heating and optical observation. |
| Optical Rotation | Polarimetry | Measures specific rotation of chiral compounds using sodium D-line light in a defined path-length cell. |
| Appearance | Visual Inspection | Assesses physical state, color, and clarity of sample against standard reference under controlled lighting. |
| pH of Aqueous Solution | pH Meter | Measures hydrogen ion activity in saturated aqueous suspension using calibrated glass electrode. |
| Particle Size Distribution | Laser Diffraction | Determines size distribution of solid particles in suspension by analyzing angular scattering pattern of laser beam. |
Technical Specifications of 2-Chloro-5-hydroxymethylp...
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 85–89 °C |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
| Identification (NMR) | Conforms to reference standard |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Chloro-5-hydroxymethylp...
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Chloro-5-hydroxymethylp...
Packaging of 2-Chloro-5-hydroxymethylp...
Industrial 2-Chloro-5-hydroxymethylp... Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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