(R)-(-)-3-Pyrrolidinol hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 104706-47-0 |
| Product name | (R)-(-)-3-Pyrrolidinol hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (R)-(-)-3-Pyrrolidinol hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (R)-(-)-3-Pyrrolidinol hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (R)-(-)-3-Pyrrolidinol hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Key chiral intermediate for the anti-HIV drug abacavir | Chiral pool synthesis or asymmetric synthesis to construct the pyrrolidine ring in drug molecules |
| Pharmaceutical Industry | Critical building block for nucleoside antiviral drug synthesis | Nucleophilic substitution or coupling reactions with purine or pyrimidine bases |
| Pharmaceutical Industry | Chiral building block for pharmaceutical molecules | Serves as a chiral structural unit for constructing novel drug molecules containing hydroxyl-substituted pyrrolidine scaffolds |
| Organic Synthesis | Precursor to chiral ligands or chiral catalysts | Used in the development and optimization of asymmetric catalytic systems |
| Research Reagents | Chiral reference standard | Applied in pharmaceutical analysis, chiral purity testing, and optical rotation measurement |
Manufacturing Quality Control of (R)-(-)-3-Pyrrolidinol hydrochloride
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | Compare the infrared absorption spectrum of the sample with standard reference spectra to confirm consistency of functional group characteristic peaks. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Determine chemical shifts, coupling constants, and integration areas of hydrogen atoms in the molecule to verify structural features. | |
| Optical Rotation Measurement | Measure specific optical rotation under a specified wavelength (typically sodium D line, 589 nm) to confirm optical purity and (R)-configuration. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use reversed-phase HPLC with appropriate mobile phases (e.g., methanol/water or acetonitrile/buffer salt) to separate the main component, quantifying via external standard method or area normalization. |
| Acid-Base Titration | Titrate free acid in the hydrochloride salt using strong base (e.g., NaOH) to calculate the content of the active ingredient (suitable for high-purity samples). | |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Simultaneously detect potential organic impurities (e.g., enantiomers, synthesis by-products, degradation products) under the conditions used for content determination, with established impurity limits. |
| Enantiomeric Purity | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Use chiral stationary phase columns to separate (R) and (S) enantiomers, determining enantiomeric excess (e.e.) or enantiomeric impurity levels. |
| Water Content | Karl Fischer Titration | Determine moisture content using either volumetric or coulometric Karl Fischer methods, suitable for hydrates or hygroscopic hydrochloride salts. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection to detect residual organic solvents (e.g., methanol, ethanol, dichloromethane) from synthesis or purification processes. |
| Residue on Ignition / Ash Content | Ignition Weight Method | Subject the sample to high-temperature incineration to constant weight to determine inorganic impurity levels, assessing residues from inorganic salts or metal catalysts. |
| pH Value | pH Meter Measurement | Prepare a solution at a defined concentration and measure its acidity or alkalinity using a calibrated pH meter, reflecting the dissociation characteristics of the hydrochloride salt and possible influence of impurities. |
| Appearance and Physical Properties | Visual Inspection | Observe color, crystalline form, odor, and other physical characteristics; should be white to off-white crystalline powder with no unusual odor. |
Technical Specifications of (R)-(-)-3-Pyrrolidinol hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -8.0 to -7.5 deg (c=1, H2O) |
| Melting Point | 148 to 152 °C |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (R)-(-)-3-Pyrrolidinol hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (R)-(-)-3-Pyrrolidinol hydrochloride
Safety Information of (R)-(-)-3-Pyrrolidinol hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (R)-(-)-3-Pyrrolidinol hydrochloride
Industrial (R)-(-)-3-Pyrrolidinol hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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