H-D-Val-OtBu.HCl Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 104944-18-5 |
| Product name | H-D-Val-OtBu.HCl |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for H-D-Val-OtBu.HCl
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk H-D-Val-OtBu.HCl Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of H-D-Val-OtBu.HCl
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Chiral intermediate for the synthesis of the antidiabetic drug sitagliptin | Used as a chiral building block in asymmetric synthesis to construct the β-amino acid structure via deprotection, coupling, and related steps |
| Pharmaceutical Industry | Protected amino acid monomer for peptide-based drug synthesis | Applied as an Nα-tert-butoxycarbonyl (Boc)- and side-chain hydrochloride-protected valine derivative in solid-phase peptide synthesis (SPPS) |
| Organic Synthesis | Chiral auxiliary or precursor to asymmetric catalytic ligands | Derivatized to produce chiral phosphine or oxazoline ligands for asymmetric reactions catalyzed by transition metals |
Manufacturing Quality Control of H-D-Val-OtBu.HCl
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC with UV detection | Quantification based on peak area comparison against a certified reference standard using reversed-phase chromatography. |
| Enantiomeric Purity | Chiral HPLC or Chiral GC | Separation of D- and L-enantiomers on a chiral stationary phase; D-isomer content determined by relative peak area. |
| Loss on Drying (LOD) | Gravimetric thermogravimetry (105 °C, 2 h) | Mass loss upon controlled heating under specified conditions reflects volatile content (e.g., residual solvents, water). |
| Residual Solvents (e.g., MTBE, EtOAc, MeOH) | GC-FID or GC-MS | Volatile organic impurities quantified by headspace or direct injection, calibrated against internal/external standards. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS or ICP-OES | Total elemental metal content determined after acid digestion via atomic emission or mass spectrometric detection. |
| Chloride Ion (Cl⁻) Impurity | Ion Chromatography (IC) or potentiometric titration with AgNO₃ | Quantification of chloride anions via conductivity detection (IC) or argentometric endpoint detection. |
| pH (1% w/v aqueous solution) | Potentiometric pH measurement | Hydrogen ion activity measured using calibrated glass electrode in standardized aqueous suspension. |
| Specific Optical Rotation | [α]D²⁰ | Measurement of plane-polarized light rotation in solution at 20 °C using sodium D-line (589 nm); confirms chiral integrity and concentration. |
| Residual Water (Karl Fischer) | Coulometric or volumetric Karl Fischer titration | Quantitative determination of water content via iodine–sulfur dioxide redox reaction in anhydrous methanol medium. |
| Related Substances (Impurity Profile) | HPLC with UV detection (gradient method) | Identification and quantification of structurally related impurities (e.g., N-Boc-D-valine, D-valine, diastereomers) using retention time and response factors. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity to determine volume-based particle size distribution in dispersed solid sample. |
| Microbial Contamination (TAMC, TYMC) | Membrane filtration followed by agar plate culture | Enumeration of aerobic mesophilic bacteria and yeasts/molds per pharmacopoeial compendia (e.g., USP <61>). |
Technical Specifications of H-D-Val-OtBu.HCl
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178-182°C |
| Optical Rotation | -22.0 to -20.0° (c=1, in 6M HCl) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of H-D-Val-OtBu.HCl
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of H-D-Val-OtBu.HCl
Packaging of H-D-Val-OtBu.HCl
Industrial H-D-Val-OtBu.HCl Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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