N-Methyl-4-piperidinol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 106-52-5 |
| Product name | N-Methyl-4-piperidinol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Methyl-4-piperidinol
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Methyl-4-piperidinol Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Methyl-4-piperidinol
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for synthesizing anticholinergic agents such as glycopyrronium bromide and pirenzepine | Reacted with brominating reagents (e.g., hydrogen bromide or elemental bromine) to form quaternary ammonium salts, followed by salt formation and purification |
| Pharmaceuticals | Key intermediate for synthesizing opioid receptor antagonists naloxone and naltrexone | Used to construct the morphinan backbone via multi-step reactions including oxidation and condensation |
| Pesticides | Structural building block for novel insecticides and plant growth regulators | Employed as a nitrogen-containing heterocyclic module in coupling or alkylation reactions |
| Materials | Used to prepare high-performance polyurethane catalysts and functionalized polymer monomers | Reacted with isocyanates to produce piperidine-containing urea-based catalysts |
Manufacturing Quality Control of N-Methyl-4-piperidinol
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Utilizes a C18 reversed-phase column with gradient elution using water-methanol or acetonitrile, and UV detection (210–254 nm) for quantification of the main component. The content is calculated via external standard or internal standard method, suitable for high-precision quantitative analysis. |
| Moisture Content | Karl Fischer Titration | Employs a reagent composed of iodine, sulfur dioxide, pyridine, and methanol that reacts quantitatively with water. Moisture is determined by potentiometric or coulometric titration, enabling precise measurement of trace water in organic solvents (accuracy down to ppm level). |
| Residual Solvents | Gas Chromatography (GC) | Uses capillary columns (e.g., DB-624 or HP-INNOWAX) and FID detection; follows USP/EP methods to determine residual solvents such as ethanol, acetone, and acetonitrile. Quantification is performed using an internal standard method, complying with ICH Q3C guidelines. |
| Heavy Metal Impurities | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After acid digestion of samples, AAS is used to determine levels of lead, cadmium, mercury, arsenic, and other heavy metals; alternatively, Inductively Coupled Plasma Mass Spectrometry (ICP-MS) enables simultaneous multi-element analysis, meeting pharmacopoeial limits for heavy metals. |
| Related Substances (Impurity Profile) | HPLC-UV or HPLC-MS | Gradient-elution HPLC separates degradation products and synthetic intermediates; UV detection provides initial screening, while coupling with mass spectrometry (LC-MS) enables structural identification. Single and total impurities are controlled within specified limits (typically 0.1%–0.5%). |
| pH Value | Glass Electrode pH Meter Method | Sample is prepared as a solution at a defined concentration (e.g., 1% w/v), then measured directly with a calibrated pH meter at 25°C. Ensures the value falls within the pharmaceutical specification range (usually 5.0–7.5). |
| Melting Point | Capillary Melting Point Apparatus Method | Dried sample is loaded into a capillary tube and heated slowly in a melting point apparatus. The initial and complete melting temperatures are recorded, used for identification and purity assessment (typical range: 85–90°C). |
| UV Absorption Characteristics | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Sample solution (e.g., in methanol or water) is scanned across 200–400 nm wavelength range to identify characteristic absorption peaks (e.g., λmax ≈ 215 nm), used for qualitative identification and concentration estimation. |
| Content Uniformity (in Formulations) | HPLC or LC-MS (for formulations) | When active pharmaceutical ingredient is used in dosage forms, content uniformity must be tested according to pharmacopoeial requirements. Ten individual samples are analyzed; RSD ≤ 10% is considered acceptable. |
Technical Specifications of N-Methyl-4-piperidinol
| Test Item | Specification |
|---|---|
| Appearance | Brown slush |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Refractive Index (n20/D) | 1.475–1.485 |
| Relative Density (20°C/25°C) | 1.020–1.040 g/cm³ |
| Odor | Characteristic piperidinyl odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Methyl-4-piperidinol
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Methyl-4-piperidinol
Packaging of N-Methyl-4-piperidinol
Industrial N-Methyl-4-piperidinol Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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