2-Bromo-5-fluoro-4-iodopyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1061357-89-8 |
| Product name | 2-Bromo-5-fluoro-4-iodopyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Bromo-5-fluoro-4-iodopyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Bromo-5-fluoro-4-iodopyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Bromo-5-fluoro-4-iodopyridine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Fluorine-, iodine-, and bromine-containing heterocyclic building blocks for synthesizing kinase inhibitor candidates (e.g., BTK and EGFR inhibitors) | Transition metal-catalyzed reactions, including Suzuki coupling, Heck coupling, and Buchwald–Hartwig amination |
| Agrochemical R&D | Polychlorinated or polyhalogenated pyridine structural motifs in novel insecticidal and fungicidal molecules | Used as key intermediates in ring construction or functional group transformation to optimize target activity and metabolic stability |
| Materials Science | Structural modification units for electron-transport layers or emissive dopants in organic light-emitting diode (OLED) devices | Introduction of conjugated extension groups via halogen-directed C–H activation or cross-coupling to tune HOMO/LUMO energy levels |
Manufacturing Quality Control of 2-Bromo-5-fluoro-4-iodopyridine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV or UPLC-MS | Separation and quantification of impurities (e.g., regioisomers, dehalogenated by-products) using gradient HPLC/UV or mass-selective detection. |
| Residual Solvents | GC-FID or GC-MS | Headspace GC analysis with flame ionization or mass spectrometric detection to quantify solvents (e.g., DMF, THF, MeOH) per ICH Q3C guidelines. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion, achieving sub-ppb sensitivity. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with sample moisture. |
| Residue on Ignition | Gravimetric Analysis | Weight loss on ignition at 700–800 °C to determine inorganic ash content after complete organic matrix combustion. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion using laser scattering to report D10, D50, D90 values per USP <429>. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement by controlled heating; sharp melting range confirms crystallinity and absence of significant eutectics. |
| Chloride Impurity | Ion Chromatography (IC) | Separation and conductivity-based quantification of chloride ions released during alkaline hydrolysis or extraction. |
| Elemental Composition (C, H, N, Halogens) | Combustion Analysis (CHN/X) + Halogen-Specific Detection | Oxidative combustion followed by thermal conductivity (C/H/N) and microcoulometric (Cl/Br/I) or pyrohydrolytic (F) detection. |
| Optical Rotation | Polarimetry | Measurement of specific rotation at specified wavelength (e.g., Na D-line) to confirm chiral purity if applicable (though compound is achiral, used for batch consistency). |
Technical Specifications of 2-Bromo-5-fluoro-4-iodopyridine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Melting Point | 124–128°C |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Bromo-5-fluoro-4-iodopyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Bromo-5-fluoro-4-iodopyridine
Safety Information of 2-Bromo-5-fluoro-4-iodopyridine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 2-Bromo-5-fluoro-4-iodopyridine
Industrial 2-Bromo-5-fluoro-4-iodopyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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