(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1062580-52-2 |
| Product name | (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1062580-52-2
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1062580-52-2 Supplier from China
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Industrial Applications of 1062580-52-2
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for synthesizing antidiabetic drugs (e.g., DPP-4 inhibitors) | Used as a chiral intermediate in coupling and reductive amination reactions to construct the target molecular scaffold |
| Chemical R&D | Chiral reagent or ligand precursor | Applied in asymmetric synthesis; structurally modified to serve as a catalyst component |
| Pharmaceuticals | Critical chiral building block in API synthesis | Incorporated into the active molecular structure via deprotection, acylation, or alkylation steps |
Manufacturing Quality Control of 1062580-52-2
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Chemical Structure Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | Utilize ¹H NMR and ¹³C NMR to analyze chemical shifts, coupling constants, and other parameters of hydrogen and carbon atoms to confirm the stereochemistry and molecular structure of the target compound. |
| Purity Determination | High-Performance Liquid Chromatography (HPLC) | Employ reversed-phase chromatographic columns with UV detection (e.g., 210–254 nm) to quantitatively determine the peak area of the main component, calculating purity (typically required ≥98.0%). |
| Chiral Purity / Enantiomeric Excess | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Use chiral stationary phase columns to separate enantiomers; determine the content of (3R,4R) isomer to ensure non-enantiomeric or enantiomeric impurities are ≤0.5%. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Loss on Drying Method | Dry samples at a specified temperature (e.g., 105°C) until constant weight, measuring the percentage mass loss due to volatile substances (including moisture). |
| Residual Solvents | Gas Chromatography (GC) | Follow ICH Q3C guidelines; use headspace injection with GC-FID or GC-MS to quantify residual organic solvents (e.g., methanol, ethyl acetate). |
| Inorganic Impurities (Heavy Metals) | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After sample digestion, detect trace levels of heavy metals such as lead, arsenic, cadmium, and mercury using ICP-MS, ensuring compliance with pharmacopoeial limits (e.g., <10 ppm). |
| pH Value | pH Meter Measurement | Prepare an aqueous solution at a defined concentration (e.g., 1% w/v), then measure pH using a calibrated pH meter to assess stability of the hydrochloride salt form. |
| Melting Point | Capillary Melting Point Method | Determine the temperature range from initial melting to complete melting of solid samples for identification and preliminary purity assessment (should match the standard reference material's melting range). |
| Specific Rotation | Polarimeter Measurement | Prepare a solution of specified concentration and measure optical rotation under sodium D line (589 nm) to verify consistency of chiral center configuration. |
| Related Substances (Impurity Profiling) | HPLC Gradient Elution Method | Apply gradient elution to separate and quantify process-related impurities and degradation products; individual impurities ≤0.1%, total impurities ≤0.5% (adjustable based on regulatory submission requirements). |
Technical Specifications of 1062580-52-2
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.5% (HPLC) |
| Total Impurities | <=1.5% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Optical Rotation | +28.5 to +31.5° (c=1, in 1M HCl) |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1062580-52-2
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1062580-52-2
Packaging of 1062580-52-2
Industrial 1062580-52-2 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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