2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 106461-41-0 |
| Product name | 2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 106461-41-0
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 106461-41-0 Supplier from China
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Industrial Applications of 106461-41-0
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of the antidepressant mirtazapine | Converted into the active pharmaceutical ingredient (API) via cyclization, substitution, or reduction steps in the multi-step mirtazapine synthesis route |
| Pharmaceutical R&D | Lead compound for structure–activity relationship (SAR) studies and optimization of novel central nervous system (CNS) therapeutics | Chemical modifications of the piperazine moiety, triazolone ring, or aryl substituents are performed to evaluate modulation of neurotransmitter receptors, including 5-HT and NE receptors |
Manufacturing Quality Control of 106461-41-0
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) High-Performance Liquid Chromatography (HPLC) Nuclear Magnetic Resonance Spectroscopy (NMR) |
IR: Confirms molecular structure based on characteristic functional group absorption peaks; HPLC: Qualitative identification by comparing retention time with reference standard; NMR (¹H/¹³C): Provides information on molecular framework and substituents, used for structural confirmation. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) Ultra-Performance Liquid Chromatography (UPLC) |
Uses reversed-phase columns (e.g., C18) with gradient elution to detect the main component and potential process impurities or degradation products. Impurity levels are typically calculated using the area normalization method or the main component method with correction factors. |
| Assay (Content Determination) | High-Performance Liquid Chromatography (HPLC) | Quantifies the main component using external or internal standard methods with a UV detector (e.g., 254 nm), ensuring linearity, precision, and accuracy meet pharmacopoeial requirements. |
| Residual Solvents | Gas Chromatography (GC) | Headspace or direct injection with FID detection. Quantitative analysis of organic solvents (e.g., methanol, ethanol, dichloromethane) used in synthesis, following ICH Q3C guidelines. |
| Loss on Drying | Thermogravimetric Analysis (TGA) Constant Weight Drying at Atmospheric Pressure |
Drying to constant weight at a specified temperature (e.g., 105°C) to determine the percentage weight loss due to volatile substances, primarily moisture. |
| Sulfated Ash (Residue on Ignition) | High-Temperature Ignition Method | Sample is charred and then ignited at 700–800°C to determine the amount of inorganic residue, used to assess inorganic salts or metal catalyst residues. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) Inductively Coupled Plasma Mass Spectrometry (ICP-MS) |
After sample preparation per pharmacopoeial methods, determines elemental impurities such as lead, cadmium, mercury, and arsenic. ICP-MS offers higher sensitivity and is suitable for strict limit controls. |
| Water Content | Karl Fischer Titration | Highly specific and accurate for determining trace moisture. Available in volumetric (for higher water content) and coulometric (for trace water) methods. |
| Crystal Form (if applicable) | X-Ray Powder Diffraction (XRPD) Differential Scanning Calorimetry (DSC) |
XRPD distinguishes different crystalline forms; DSC assists in evaluating crystalline purity and polymorphism based on melting behavior. |
| Solution Clarity and Color | Visual Comparison Method UV-Visible Spectrophotometry |
Solution is prepared as per pharmacopoeial requirements and compared visually with standard turbidity/color solutions, or absorbance is measured at specific wavelengths to assess solution appearance quality. |
Technical Specifications of 106461-41-0
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 178–182°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 106461-41-0
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
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Industrial 106461-41-0 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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