Diethyl acetamidomalonate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1068-90-2 |
| Product name | Diethyl acetamidomalonate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Diethyl acetamidomalonate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Diethyl acetamidomalonate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Diethyl acetamidomalonate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of antipyretic and analgesic drug intermediates | Used as an organic synthesis intermediate to prepare drug molecules containing an acetylamino group, with the target compound scaffold constructed via hydrolysis, decarboxylation, and related reactions |
| Chemical Research | Organic synthesis reagent | Employed in laboratory-scale synthesis of complex organic molecules; participates in condensation, substitution, and other reactions as a malonic ester derivative within multistep synthetic routes |
| Pesticides | Synthesis of pesticide intermediates | Applied as a precursor for introducing amino functionality in the synthesis pathways of specific insecticides or herbicides, undergoing multistep transformations to yield the active ingredient |
Manufacturing Quality Control of Diethyl acetamidomalonate
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Characteristics | Visual Inspection + Physical Property Measurement | Observe the sample's color and physical state (typically white or off-white crystalline powder); determine melting point (literature value: approximately 125–128 °C) to verify compliance with specifications. |
| Assay (Active Ingredient Purity) | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with aqueous-acetonitrile or methanol mobile phase, detect using a UV detector (wavelength 210–220 nm), and calculate active ingredient content by external or internal standard method; typically required to be ≥98.0%. |
| Residual Solvents | Gas Chromatography (GC) | Employ headspace or direct injection with a DB-624 or PLOT column and FID detector to quantify residual solvents such as ethanol and ethyl acetate, in compliance with ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Utilize the iodine-sulfur dioxide-pyridine-methanol system that reacts quantitatively with water to determine moisture content; typically controlled to ≤0.5% (w/w), in accordance with pharmaceutical standards. |
| Related Substances (Impurity Profile) | HPLC (Impurity Detection) | Apply gradient elution HPLC to detect potential impurities such as unreacted diethyl malonate, acetamide, or deacetylated products; quantification limit ≤0.1%, individual impurity ≤0.5%, total impurities ≤1.0%. |
| Chlorides | Silver Nitrate Titration / Ion Chromatography | Dissolve the sample in water, acidify with nitric acid, add silver nitrate solution, and observe turbidity or detect Cl⁻ concentration via ion chromatography; comply with pharmacopoeial limits (e.g., ≤0.01%). |
| Sulfates | Barium Chloride Turbidimetry | Add hydrochloric acid and barium chloride to the sample solution to form barium sulfate precipitate; compare turbidity with a standard solution to control sulfate content ≤0.01%. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After ashing or digestion of the sample, measure concentrations of heavy metals such as lead, cadmium, mercury, and arsenic; comply with USP/EP pharmacopoeial limits (e.g., Pb ≤5 ppm). |
| Melting Point | Capillary Melting Point Apparatus | Determine the melting range using a digital melting point apparatus; should match the literature value (125–128 °C) with a deviation of ≤2 °C, used for preliminary purity assessment. |
| Acidity/Alkalinity (pH) | pH Meter Measurement | Prepare a 1% aqueous solution of the sample and measure pH; typically required to be within 5.0–7.5, reflecting hydrolysis or acidic impurity levels. |
| Infrared Spectroscopy (IR) | Fourier Transform Infrared Spectroscopy (FT-IR) | Compare with a reference spectrum to confirm characteristic functional groups (e.g., amide I/II bands, ester carbonyl, N–H stretching vibrations) for structural confirmation. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Proton NMR Spectroscopy | Measure in DMSO-d₆ or CDCl₃ solvent; analyze characteristic proton signals (e.g., –CH₂–ester, –NHAc, –CH–) for structural verification and qualitative impurity identification. |
Technical Specifications of Diethyl acetamidomalonate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Melting Point | 102.0-106.0°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Diethyl acetamidomalonate
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NMR Spectra of Diethyl acetamidomalonate
Packaging of Diethyl acetamidomalonate
Industrial Diethyl acetamidomalonate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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