China Factory Direct
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| CAS number | 1075705-01-9 |
| Product name | 4-fluoro-2-Methoxy-5-nitroaniline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for synthesizing antitumor or antibacterial agents | Organic synthesis, multistep reactions |
| Pesticides | Active ingredient in fluorinated pesticide formulations | Nitration, fluorination, methoxylation |
| Dyes | Intermediate for synthesizing fluorinated azo dyes | Diazotization, coupling reactions |
| Materials Science | Monomer or modifier for fluorinated polymer synthesis | Polymerization, functionalization |
| Test Item | Common Testing Methods | Method Overview |
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| Appearance and Physical Properties | Visual Inspection, Melting Point Determination | Observe sample color, crystal form, presence of impurities or particulates; determine melting point range (literature value approximately 120–125 °C) to assess purity. |
| Content Assay (Main Component Purity) | High-Performance Liquid Chromatography (HPLC) | Use C18 column with acetonitrile-water (containing 0.1% formic acid) as mobile phase, UV detector (254 nm or 280 nm), external standard method for quantification, capable of separating and quantifying the main component and major impurities. |
| Related Substances (Impurity Profile) | HPLC or UPLC | Employ gradient elution program to detect potential impurities such as unreacted starting materials (e.g., fluoronitrobenzene, methoxyaniline derivatives), oxidation products, reduction products, etc., with impurity levels calculated as a percentage of the main component peak area. |
| Water Content | Karl Fischer Titration | Utilize the specific reaction between iodine, sulfur dioxide, pyridine, and methanol; measure trace water using potentiometric or coulometric Karl Fischer titration, meeting pharmacopoeial requirements (typically ≤0.5%). |
| Solvent Residuals | Gas Chromatography (GC) | Use headspace or direct injection with DB-624 or HP-INNOWAX column and FID detector to detect residual organic solvents such as ethanol, ethyl acetate, DMF, dichloromethane, conforming to ICH Q3C guidelines. |
| Fluorine Content | Ion Selective Electrode (ISE) or Ion Chromatography | Convert fluorine in samples to fluoride ions via alkaline fusion or oxygen bomb combustion, then quantify using fluoride ion selective electrode or ion chromatography to ensure fluorine content matches theoretical value (theoretical F content ≈10.9%). |
| Nitro Group Confirmation | Fourier Transform Infrared Spectroscopy (FT-IR) | Confirm the presence of nitro group through characteristic absorption peaks (asymmetric and symmetric stretching vibrations at ~1520 cm⁻¹ and ~1340 cm⁻¹), excluding interference from other nitrogen-containing functional groups. |
| Structural Elucidation | Nuclear Magnetic Resonance Spectroscopy (¹H-NMR, ¹³C-NMR) | Measure in DMSO-d₆ or CDCl₃ solvent; confirm substitution pattern on benzene ring (ortho/meta/para positions) based on chemical shifts and coupling constants to verify molecular structure accuracy. |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After wet digestion of samples, determine residual heavy metals such as lead, cadmium, mercury, and arsenic, complying with pharmacopoeial limits (e.g., Pb ≤10 ppm). |
| Solubility and pH (Solution Properties) | Solubility Testing, pH Meter | Determine solubility in water, ethanol, ethyl acetate, etc.; prepare saturated aqueous solution and measure pH (theoretically weakly basic, pH ≈6–7) to evaluate dissolution behavior during process development. |
| Particle Size Distribution (if solid powder) | Laser Particle Size Analyzer | If used as an API, determine particle size parameters such as D10, D50, D90 to ensure flowability and homogeneity meet formulation processing requirements. |
| Test Item | Specification |
|---|---|
| Appearance | Orange solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 128–132°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.