α-Lipoic Acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1077-28-7 |
| Product name | α-Lipoic Acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Food GradeCosmetic Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for α-Lipoic Acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk α-Lipoic Acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of α-Lipoic Acid
| Industry | Application | Processing |
|---|---|---|
| Pharmaceuticals | Used as an antioxidant and mitochondrial metabolic cofactor in the treatment of diabetic peripheral neuropathy, liver disorders, and heavy metal poisoning | Formulated into oral dosage forms (tablets, capsules) or intravenous solutions; co-administered with B-complex vitamins to enhance therapeutic efficacy |
| Dietary Supplements | Used as a functional food ingredient to support energy metabolism, alleviate fatigue, and mitigate age-related decline | Incorporated into softgel capsules, tablets, or multivitamin formulations; commonly co-formulated with coenzyme Q10, alpha-ketoglutaric acid, and other synergistic actives |
| Cosmetics | Used as a skin antioxidant active ingredient in anti-wrinkle, skin-brightening, and photoprotective products | Incorporated into oil-in-water emulsion systems such as serums and creams at typical concentrations of 0.1–1.0%; requires light-protected, airtight storage to maintain stability |
| Feed Additives | Used as an animal nutrition enhancer to improve rumen health in ruminants and antioxidant capacity in poultry | Pre-blended into vitamin premixes, then added to complete feed after high-temperature pelleting; recommended inclusion level: 50–200 mg/kg feed |
Manufacturing Quality Control of α-Lipoic Acid
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Assay | High-Performance Liquid Chromatography (HPLC) | Utilizes a reversed-phase C18 column with a UV detector (typically at wavelengths of 210–230 nm), using mobile phases such as methanol-phosphate buffer. Quantification of alpha-lipoic acid is performed via external or internal standard method, offering high sensitivity and resolution. |
| Purity Analysis | High-Performance Liquid Chromatography (HPLC) | Assesses purity by calculating the percentage of the main peak area in the HPLC chromatogram. Simultaneously detects related substances (e.g., degradation products, isomers), typically requiring total impurities to be within specified limits (e.g., ≤1.0%). |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Separates alpha-lipoic acid and its related impurities (e.g., dimers, oxidation products, R/S isomers) using gradient or isocratic elution. Impurity content is calculated by comparison with reference standards or self-reference methods. |
| Crystal Form Analysis | X-ray Powder Diffraction (XRD) | Analyzes the crystalline structure of solid samples to identify different polymorphs or monitor crystal form consistency, ensuring batch-to-batch stability. |
| IR Identification | Fourier Transform Infrared Spectroscopy (FTIR) | Compares the sample spectrum with a reference standard to confirm molecular structure via characteristic absorption peaks (e.g., C=O stretching vibration, S–S bond), used for authenticity verification of raw materials. |
| Specific Optical Rotation | Polarimetry | Measures the optical activity of alpha-lipoic acid using a polarimeter at a specified temperature and wavelength to distinguish between the R-form (active form) or racemic mixtures. |
| Water Content | Karl Fischer Titration | Determines water content in samples via volumetric or coulometric methods to control formulation stability; water content is typically required to be ≤1.0%. |
| Residual Solvents | Gas Chromatography (GC) | Detects residual organic solvents (e.g., methanol, ethanol, acetone) from the manufacturing process using headspace sampling coupled with a flame ionization detector (FID), in compliance with ICH Q3C guidelines. |
| Particle Size Distribution | Laser Diffraction Particle Size Analysis | Analyzes particle size in solid active pharmaceutical ingredients or formulations, influencing solubility and bioavailability, ensuring batch-to-batch consistency. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determines residues of heavy metals such as lead, cadmium, arsenic, and mercury to ensure compliance with pharmacopeial or international standards (e.g., USP, EP) for permissible limits. |
Technical Specifications of α-Lipoic Acid
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.5% (GC) |
| Melting Point | 47.0–49.0°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Optical Rotation | +55° to +65° (c=1, in chloroform) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of α-Lipoic Acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of α-Lipoic Acid
Packaging of α-Lipoic Acid
Industrial α-Lipoic Acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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