H-PRO-PNA TFA Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 108321-19-3 |
| Product name | H-PRO-PNA TFA |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Material GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for H-PRO-PNA TFA
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk H-PRO-PNA TFA Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of H-PRO-PNA TFA
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral catalyst precursor for asymmetric synthesis of β-amino acid derivatives and nitrogen-containing heterocyclic compounds | Used as a ligand or co-catalyst in palladium-catalyzed C–H activation and asymmetric alkene amination reactions; requires in situ complexation with metal salts (e.g., Pd(OAc)₂) under anhydrous and anaerobic conditions |
| Organic Synthesis | Non-natural α-amino acid building block for constructing protease inhibitor and peptide drug intermediates | Deprotection of the trifluoroacetate group via basic hydrolysis (e.g., K₂CO₃/MeOH), followed by incorporation into solid-phase peptide synthesis (SPPS) or solution-phase coupling reactions (e.g., EDC/HOBt-mediated condensation) |
| Materials Science | Chiral functionalization reagent for preparing chiral conductive polymers and circularly polarized luminescent (CPL) materials | Introduction of the p-nitroanilino group into conjugated backbones via diazo coupling or Ullmann coupling, followed by reduction-cyclization to construct chiral nitrogen-containing fused-ring structures |
Manufacturing Quality Control of H-PRO-PNA TFA
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reverse-phase HPLC with UV detection at 254 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and detection of impurities using gradient HPLC-UV; identification and quantification against reference standards or threshold limits. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify residual solvents (e.g., methanol, ethyl acetate, DCM) based on calibrated response factors. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine water content via stoichiometric reaction. |
| Heavy Metals | ICP-MS | Quantitative determination of elemental impurities (e.g., Pb, Cd, As, Hg) by inductively coupled plasma mass spectrometry after acid digestion. |
| Chloride Content | Ion Chromatography | Separation and conductivity detection of chloride ions in aqueous solution using anion-exchange column and suppressed conductivity detection. |
| Optical Rotation | [alpha]D | Measurement of specific optical rotation using a digital polarimeter at 20 C and sodium D-line (589 nm) to confirm chiral integrity. |
| Residue on Ignition | Gravimetric Analysis | Ignition at 700-800 C followed by weighing of inorganic residue to assess non-volatile inorganic impurities. |
| pH (1% w/v aqueous solution) | pH Potentiometry | Measurement using calibrated pH electrode in a defined aqueous suspension to verify acidic character from TFA salt. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion using laser diffraction to determine D10, D50, D90 values per USP <429>. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per USP <61> and <62>. |
| Appearance (Color and Clarity) | Visual Inspection | Comparison of dissolved sample solution against standard color solutions (e.g., Yellowness Index) and visual assessment of clarity per USP <191>. |
Technical Specifications of H-PRO-PNA TFA
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -22.0 to -21.0 deg (c=1, in DMF) |
| Melting Point | 148 to 152 °C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of H-PRO-PNA TFA
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of H-PRO-PNA TFA
Packaging of H-PRO-PNA TFA
Industrial H-PRO-PNA TFA Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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