Fmoc-D-Asparagine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 108321-39-7 |
| Product name | Fmoc-D-Asparagine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-D-Asparagine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-D-Asparagine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-D-Asparagine
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Protecting reagent for D-asparagine residues in solid-phase peptide synthesis (SPPS) | Used as an amino-protecting group; stable under basic conditions and cleaved under acidic conditions; commonly applied in the synthesis of therapeutic peptides, peptide-based drugs, and structural probes containing D-configured amino acids |
| Pharmaceutical R&D | Chiral peptide drug intermediate for constructing candidate molecules with enhanced metabolic stability or specific conformational activity | Integrated into Fmoc-SPPS: coupled to resin, followed by iterative cycles of Fmoc deprotection, coupling, and chain elongation; the D-configuration confers resistance to proteolytic degradation |
| Biochemical Research | Synthesis of isotopically labeled or fluorescently modified peptides incorporating D-asparagine for protein interaction or enzyme kinetic studies | After Fmoc protection, the side-chain carboxyl group can be selectively activated and modified (e.g., amidation, esterification) prior to incorporation into peptide chain assembly |
Manufacturing Quality Control of Fmoc-D-Asparagine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies Fmoc-D-Asn content by UV absorbance at 268 nm using a reversed-phase C18 column and gradient elution with aqueous/organic mobile phase. |
| Chiral Purity | Chiral HPLC | Resolves D- and L-enantiomers using a chiral stationary phase; enantiomeric excess is calculated from peak area ratios. |
| Water Content | Karl Fischer Titration | Measures trace water via coulometric or volumetric titration with iodine generated electrochemically or added stoichiometrically. |
| Residual Solvents | GC-FID | Detects and quantifies residual solvents (e.g., DMF, DCM, THF) using flame ionization detection after capillary column separation. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Hg, As) at sub-ppb levels by mass spectrometric detection of ionized atoms. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic ash content by ignition at 500-600 C followed by precise weighing of the residue. |
| Specific Optical Rotation | Polarimetry | Determines optical activity using sodium D-line light; rotation angle correlates with enantiomeric composition and concentration. |
| pH of Solution | Potentiometric pH Measurement | Measures hydrogen ion activity in a 1% w/v aqueous solution using calibrated glass electrode and reference electrode. |
| Related Substances | HPLC-UV | Identifies and quantifies structurally related impurities (e.g., Fmoc-Asp-OH, deprotected Asn, diketopiperazine) using UV detection. |
| Loss on Drying | Thermogravimetric Analysis | Determines volatile content by measuring mass loss under controlled heating (e.g., 105 C, 2 h) in a ventilated oven. |
| Microbial Contamination | Membrane Filtration | Detects aerobic microorganisms by filtration, membrane transfer to soybean-casein digest agar, and incubation per USP <61>. |
| Particle Size Distribution | Laser Diffraction | Measures particle size distribution in dry powder form using Mie theory-based scattering pattern analysis of dispersed particles. |
Technical Specifications of Fmoc-D-Asparagine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | +10.0 to +14.0 deg (c=1, in DMF) |
| Melting Point | 178 to 182 °C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-D-Asparagine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-D-Asparagine
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Industrial Fmoc-D-Asparagine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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