China Factory Direct
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| CAS number | 108554-34-3 |
| Product name | 4-OXO-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Synthesis | Used as a pharmaceutical intermediate for synthesizing biologically active piperidine-based compounds | Applied in multi-step synthesis pathways—including esterification and reductive amination—to construct the target molecular structure |
| Pharmaceutical R&D | Used in the development of antipsychotic, antidepressant, and central nervous system (CNS) disorder therapeutics | Applied as a lead compound or critical structural motif for modification and optimization during targeted receptor screening |
| Organic Synthesis | Used as a versatile synthetic building block for constructing nitrogen-containing heterocyclic compounds | Applied in diverse derivatization via selective functional group transformations—such as hydrolysis, reduction, and coupling reactions |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210-220 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3A/B. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection for quantification of Class 2 and 3 solvents (e.g., methanol, ethyl acetate) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction with water. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light to confirm chiral integrity and enantiomeric purity. |
| Heavy Metals | ICP-MS | Quantitative analysis of Pb, Cd, Hg, As, and other toxic elements after acid digestion, using inductively coupled plasma mass spectrometry. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using suppressed conductivity detection after aqueous extraction. |
| Residual Catalyst (Pd) | ICP-OES | Determination of palladium residue post-hydrogenation using inductively coupled plasma optical emission spectroscopy after microwave digestion. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement by observing solid-to-liquid phase change under controlled heating rate. |
| Appearance | Visual Inspection | Assessment of physical state, color, and absence of visible particulates or foreign matter under controlled lighting and against established reference standards. |
| pH (1% w/v aqueous solution) | Potentiometric pH Measurement | Determination of hydrogen ion activity using calibrated glass electrode in a standardized aqueous suspension. |
| Loss on Drying | Gravimetric (Thermogravimetric) | Mass loss measurement after drying at specified temperature (e.g., 105 C) under vacuum or nitrogen until constant weight is achieved. |
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 124–128°C |
| Optical Rotation | -15.0 to -19.0° (c=1, in methanol) |
| Heavy Metals | <=10 ppm |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.