Fmoc-His(Trt)-OH Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 109425-51-6 |
| Product name | Fmoc-His(Trt)-OH |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for Fmoc-His(Trt)-OH
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-His(Trt)-OH Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-His(Trt)-OH
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Used as a protecting monomer for histidine residues in peptide synthesis to prevent side reactions | Introduced at specific sites in solid-phase or solution-phase peptide synthesis using the Fmoc/tBu protection strategy |
| Biochemical Research | Preparation of custom peptides or protein sequences containing histidine for structural or functional studies | Stepwise coupling on automated synthesizers; Fmoc groups removed with piperidine, Trt groups cleaved under acidic conditions |
| Drug Development | Synthesis of peptide-based therapeutics (e.g., hormone analogs, targeted therapeutic peptides), particularly where histidine active sites must be preserved | Sequential condensation with other Fmoc-protected amino acids, followed by cleavage to release the target peptide and subsequent purification |
Manufacturing Quality Control of Fmoc-His(Trt)-OH
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, physical state, and presence of lumps. Typically appears as a white to off-white powder with no visible impurities. |
| Purity | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase C18 column with UV detection (265 nm or 220 nm). The main component purity is calculated based on retention time and peak area, generally requiring ≥98%. |
| Chiral Purity | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Utilizes a chiral chromatographic column to separate L- and D-isomers, assessing optical purity and ensuring minimal or no detectable D-isomer impurities. |
| Moisture Content | Karl Fischer Titration | Determines total water content (bound and free water) to control its impact on stability; typically requires ≤0.5%. |
| Residual Solvents | Gas Chromatography (GC) | Tests for trace organic solvents (e.g., DMF, dichloromethane, ethyl acetate) remaining from synthesis, conforming to pharmacopoeial limits. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Measures residual levels of heavy metals such as lead, mercury, cadmium, and arsenic, ensuring compliance with GMP or pharmaceutical standards (e.g., ≤10 ppm). |
| Melting Point | Melting Point Analyzer | Determines the melting temperature range, serving as an initial indicator of purity and consistency; typical range is approximately 178–182°C. |
| Infrared Spectroscopy (IR) | Fourier Transform Infrared Spectroscopy (FT-IR) | Compares with reference spectra to confirm the presence of functional groups (e.g., Fmoc, Trt protecting groups, carboxyl, imidazole ring). |
| Nuclear Magnetic Resonance (NMR) | ¹H NMR and ¹³C NMR | Performed in deuterated solvents (e.g., DMSO-d6), verifying molecular structure, substitution positions, and purity by confirming absence of impurity signals. |
| UV Absorption | UV-Visible Spectrophotometry | Exploits the characteristic absorption of the Fmoc group at ~265 nm for quantification or auxiliary purity assessment. |
| Content Determination | Titration or HPLC External Standard Method | Quantifies the actual content of the active ingredient via acid-base titration or HPLC external standard method, typically controlled within 98.0–102.0%. |
| Microbial Limits | Microbial Limit Test | Tests for total aerobic bacteria count, mold and yeast count, and control organisms (e.g., Escherichia coli), applicable to pharmaceutical-grade products. |
Technical Specifications of Fmoc-His(Trt)-OH
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 245-249°C |
| Optical Rotation | +86±8° (c=1, DMF) |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of Fmoc-His(Trt)-OH
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-His(Trt)-OH
Packaging of Fmoc-His(Trt)-OH
Industrial Fmoc-His(Trt)-OH Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply