(R)-1-Boc-3-hydroxypyrrolidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 109431-87-0 |
| Product name | (R)-1-Boc-3-hydroxypyrrolidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (R)-1-Boc-3-hydroxypyrrolidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (R)-1-Boc-3-hydroxypyrrolidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (R)-1-Boc-3-hydroxypyrrolidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Key chiral intermediate for the anti-HIV drug dolutegravir and related integrase inhibitors | Serves as a chiral building block, with its hydroxyl and heterocyclic groups participating in drug molecule construction and modification |
| Pharmaceutical Industry | Synthesis of chiral pyrrolidine derivatives in new drug development | Used in asymmetric synthesis to prepare drug candidate molecules with defined stereochemistry |
| Chemical Industry | Preparation of asymmetric synthesis catalysts or ligands | Functionalized via derivatization reactions to synthesize chiral catalysts or ligands |
| Organic Synthesis | Synthesis of complex natural products and biologically active molecules | Serves as a hydroxylpyrrolidine structural unit donor in multistep organic synthesis reactions |
Manufacturing Quality Control of (R)-1-Boc-3-hydroxypyrrolidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210–220 nm, comparing peak area against a certified reference standard. |
| Enantiomeric Excess (ee) | Chiral HPLC | Separation and quantification of (R)- and (S)-enantiomers on a chiral stationary phase; ee calculated from peak area ratio. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., THF, EtOAc, MeOH) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Coulometric or volumetric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, Ni) after acid digestion, with detection at sub-pptr levels. |
| Residual BOC Reagent (Di-tert-butyl dicarbonate) | GC-MS | Detection and quantification via gas chromatography coupled with mass spectrometry using characteristic fragment ions. |
| Related Substances | HPLC-UV (with forced degradation) | Detection of structurally related impurities (e.g., deprotected amine, dehydration products) under stressed conditions (acid/base/oxidative/thermal). |
| Residue on Ignition | Gravimetric Analysis | Determination of inorganic ash content by high-temperature incineration followed by precise weighing of residual residue. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement using calibrated capillary apparatus per USP <741>. |
| Optical Rotation | [α]D Measurement | Specific rotation determination at 589 nm (Na D-line) using a polarimeter, confirming chiral integrity and concentration-corrected enantiopurity. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder size distribution using Mie scattering theory to assess handling and formulation suitability. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | pH determination of a defined suspension (e.g., 1% w/v in water) using calibrated pH electrode per USP <791>. |
Technical Specifications of (R)-1-Boc-3-hydroxypyrrolidine
| Test Item | Specification |
|---|---|
| Appearance | Yellow-brown solid |
| Purity | >=98.0% (GC-MS) |
| Optical Rotation | -29.0 to -25.0 deg (c=1, in CHCl3) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 68.0 to 72.0 °C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (R)-1-Boc-3-hydroxypyrrolidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (R)-1-Boc-3-hydroxypyrrolidine
Safety Information of (R)-1-Boc-3-hydroxypyrrolidine
| Pictograms |   |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (R)-1-Boc-3-hydroxypyrrolidine
Industrial (R)-1-Boc-3-hydroxypyrrolidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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