N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 110764-72-2 |
| Product name | N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals / Biotechnology | Key intermediate in the synthesis of nucleic acid therapeutics, including antisense oligonucleotides (ASOs) and siRNA | Used as a protected adenosine monomer in solid-phase synthesis; the 5′-hydroxyl group is protected with a bis(4-methoxyphenyl)(phenyl)methoxy (DMT) group, and the N6 position of the adenine base is protected with a benzoyl group; incorporated into modified oligonucleotide chains via phosphotriester or phosphoramidite chemistry |
| Molecular Biology Research | Synthesis of RNA probes or primers containing 2′-O-methyl modifications | Coupled via standard phosphoramidite chemistry on DNA/RNA synthesizers to construct modified oligonucleotides with enhanced nuclease stability and target-binding affinity |
| Diagnostics Reagent Development | Building block for high-specificity molecular probes | Integrated into fluorescently or biotin-labeled oligonucleotide sequences for target recognition in applications such as in situ hybridization (ISH), quantitative PCR (qPCR), and microarray assays |
Manufacturing Quality Control of N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main compound using reverse-phase HPLC with UV detection at specified wavelength based on peak area comparison to reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities by comparing retention times and peak areas against reference standards or threshold responses. |
| Residual Solvents | GC-FID | Measures volatile organic solvents using gas chromatography with flame ionization detection, calibrated against standard solutions. |
| Water Content | Karl Fischer Titration | Determines water content via coulometric or volumetric titration using iodine-based reagent where water reacts stoichiometrically. |
| Heavy Metals | ICP-MS | Quantifies trace metal contaminants (e.g., Pb, Cd, Hg, As) by plasma ionization followed by mass spectrometric detection. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column with conductivity detection and external calibration. |
| Residual Palladium | ICP-OES | Measures palladium residue from catalytic hydrogenation using inductively coupled plasma optical emission spectroscopy. |
| Optical Rotation | Polarimetry | Determines specific rotation using sodium D-line light passing through a solution of known concentration and path length. |
| Particle Size Distribution | Laser Diffraction | Measures particle size distribution by analyzing angular variation in laser light scattering intensity from dispersed sample. |
| Microbial Limits | Membrane Filtration | Detects aerobic microorganisms by filtration, membrane transfer to culture media, incubation, and colony enumeration. |
| Residue on Ignition | Gravimetric Analysis | Determines inorganic ash content by high-temperature incineration followed by precise weighing of residual residue. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Measures hydrogen ion activity in a defined suspension using calibrated pH electrode and meter. |
Technical Specifications of N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.5% (by LC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 218–222°C |
| Identification (NMR) | Conforms to reference spectrum |
| Optical Rotation | [α]²⁰D = -12° to -16° (c = 1, in DMF) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE
Safety Information of N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE
Industrial N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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