TRIMETHYLSILYL ISOCYANATE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1118-02-1 |
| Product name | TRIMETHYLSILYL ISOCYANATE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Material GradeSpecialty GradeReagent GradeIndustrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for TRIMETHYLSILYL ISOCYANATE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk TRIMETHYLSILYL ISOCYANATE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of TRIMETHYLSILYL ISOCYANATE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates Synthesis | Used as a silyl protecting reagent for selective protection of amino groups (e.g., primary and secondary amines) to construct peptide or complex molecular frameworks | Reacted with amine substrates under anhydrous inert atmosphere (e.g., nitrogen or argon) at low temperature (–78 °C to 0 °C) to form N-trimethylsilyl carbamate intermediates, followed by mild deprotection |
| Organic Synthesis | Participates in Staudinger coupling, [2+2] cycloaddition, and other reactions to construct β-lactam or heterocyclic structures | Undergoes electrophilic addition with aldehydes, ketones, or imines under Lewis acid catalysis (e.g., TiCl₄, SnCl₄), or cooperates with phosphine reagents to enable aziridine ring-opening/ring-closure |
| Materials Science | Used as a precursor to silane coupling agents to improve interfacial compatibility between inorganic fillers (e.g., SiO₂, TiO₂) and organic polymers | Undergoes condensation with surface hydroxyl groups during sol-gel processing to introduce –NCO–Si(CH₃)₃ moieties, followed by crosslinking with polyols to form organic-inorganic hybrid networks |
| Analytical Chemistry | Used as a derivatization reagent to enhance volatility and detection sensitivity of amines and alcohols in GC-MS or LC-MS | Reacted at room temperature for 10–30 minutes in the presence of a catalytic amount of organic base (e.g., triethylamine) to yield volatile silyl carbamate or silyl carbonate derivatives |
Manufacturing Quality Control of TRIMETHYLSILYL ISOCYANATE
| Test Item | Common Test Methods | Method Overview |
|---|---|---|
| Purity (Main Component Content) | Gas Chromatography (GC) | Using a capillary column (e.g., DB-5 or HP-INNOWAX) and FID detector to measure the peak area of TMSI, purity is calculated by external or internal standard method, suitable for rapid quantitative analysis. |
| Water Content | Karl Fischer Titration | The iodine-sulfur dioxide-pyridine-methanol system reacts quantitatively with water, and trace moisture in the sample is determined by electrochemical or volumetric methods, ensuring TMSI moisture sensitivity is controlled below <0.1%. |
| Free Isocyanate Groups | Dibutylamine Titration (ISO 14898) | Excess dibutylamine reacts with free -NCO groups in TMSI, followed by back-titration of unreacted dibutylamine with hydrochloric acid to calculate -NCO content, assessing the degree of decomposition or hydrolysis. |
| Volatile Impurities | Gas Chromatography-Mass Spectrometry (GC-MS) | Volatile impurities are separated by GC and identified by MS, allowing detection of synthetic by-products or degradation products such as trimethylchlorosilane and hexamethyldisiloxane. |
| Acidity (Acid Value) | Titration (Sodium Hydroxide/Isopropanol System) | The sample's acidic impurities (e.g., HCl, silanol) are titrated with a standard NaOH isopropanol solution using phenolphthalein as an indicator, controlling the acid value ≤ 0.1 mg KOH/g. |
| Appearance and Color | Visual Inspection + Colorimeter (APHA/Pt-Co) | Observe whether the sample is clear and colorless; a colorimeter is used to measure the yellow index, ensuring no significant yellowing (APHA ≤ 20), reflecting oxidation or impurity contamination. |
| Thermal Stability | Thermogravimetric Analysis (TGA) | Under a nitrogen atmosphere, the sample is heated programmatically while monitoring the mass loss curve to evaluate its decomposition temperature (typically >100°C) and determine the presence of high-boiling impurities or polymers. |
| Residual Solvents | GC-MS or Headspace GC | For solvents possibly remaining from synthesis (e.g., toluene, diethyl ether, dichloromethane), headspace GC-MS is used for quantitative analysis, meeting ICH Q3C residual solvent limit requirements. |
| Silicon-containing Impurities (e.g., Siloxanes) | Silicon Analyzer / ICP-MS | After sample digestion, total silicon content is measured using ICP-MS, or the level of siloxane impurities is indirectly assessed through silicon-specific reactions (e.g., colorimetric reaction with fluoride). |
Technical Specifications of TRIMETHYLSILYL ISOCYANATE
| Test Item | Specification |
|---|---|
| Appearance | Colorless to almost colorless clear liquid |
| Purity | >=98.5% (GC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Refractive Index (n20/D) | 1.405–1.415 |
| Relative Density (20°C/25°C) | 0.875–0.885 g/cm³ |
| Odor | Characteristic pungent odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of TRIMETHYLSILYL ISOCYANATE
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| Lot/Batch Number | *Required fields | |
NMR Spectra of TRIMETHYLSILYL ISOCYANATE
Packaging of TRIMETHYLSILYL ISOCYANATE
Industrial TRIMETHYLSILYL ISOCYANATE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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