11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 111974-74-4 |
| Product name | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 111974-74-4
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 111974-74-4 Supplier from China
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Industrial Applications of 111974-74-4
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for antipsychotic drugs | Used as a key intermediate in the synthesis of antipsychotic drugs such as paliperidone, for constructing the molecular scaffold |
| Pharmaceutical R&D | Research for new drug development | Applied in structural modification and activity screening experiments for novel psychiatric drugs |
| Chemical Synthesis | Organic synthesis intermediate | Employed in multistep organic reactions to prepare functional sulfur- and nitrogen-containing heterocyclic compounds |
Manufacturing Quality Control of 111974-74-4
| Test Item | Commonly Used Testing Methods | Method Overview |
|---|---|---|
| Identification | UV-Visible Spectrophotometry (UV-Vis) | Measures maximum absorption of the test sample at 254 nm and 258 nm, matching the standard spectrum, used for preliminary identification. |
| Identification | Infrared Spectrophotometry (IR) | The sample is mixed with potassium bromide and pressed into a pellet. The infrared absorption spectrum is measured and compared with that of the reference substance or standard spectrum to confirm characteristic peaks (e.g., N-H, C=O, S=N). |
| Identification | HPLC Retention Time Comparison | The retention time of the main peak in the sample is determined by HPLC and compared with that of the reference standard for chromatographic identification. |
| Assay | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase C18 column with a mobile phase of phosphate buffer-methanol. The UV detector (254 nm) is used, and the content of the main component is calculated by the external standard method. |
| Related Substances (Impurity Check) | High-Performance Liquid Chromatography (HPLC) | Using the same chromatographic system, impurities are separated by gradient or isocratic elution. The detection limit is generally 0.05%–0.1%. Individual and total impurity contents are calculated. |
| Residual Solvents | Gas Chromatography (GC) | According to ICH guidelines, organic solvents possibly remaining from the manufacturing process (e.g., methanol, ethanol, acetone, dichloromethane) are tested. Headspace or direct injection is used with an FID detector. |
| Water Content | Karl Fischer Titration | Determines the water content in the sample using volumetric or coulometric methods. Typically controlled to ≤1.0%. |
| Solution Clarity and Color | Visual Comparison or Spectrophotometry | After dissolving the sample in water or a specified solvent, the clarity and color are compared visually or spectrophotometrically with standard color solutions to determine if the solution is clear and colorless or not darker than a specified standard. |
| Heavy Metals | Thioacetamide Method (Pharmacopoeia Method) | In weakly acidic conditions, heavy metals react with thioacetamide to form colored sulfides. The result is compared with a standard lead solution, with a limit generally ≤20 ppm. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Oven Method | The sample is dried at a specified temperature (e.g., 105°C) until constant weight is achieved. The percentage weight loss is measured, indicating the content of adsorbed water and volatile components. |
| Residue on Ignition | Gravimetric Method | The sample is ignited at high temperature and the residue is weighed to calculate the sulfated ash content, used to control inorganic impurities. |
| Crystal Form Analysis (if applicable) | X-Ray Powder Diffraction (XRD) | Analyzes the crystal structure of the sample to ensure it matches the standard form, preventing polymorphism from affecting stability and dissolution rate. |
Technical Specifications of 111974-74-4
| Test Item | Specification |
|---|---|
| Appearance | White to almost white powder or crystals |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 245–249 °C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 111974-74-4
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
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Industrial 111974-74-4 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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