China Factory Direct
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| CAS number | 112018-26-5 |
| Product name | D-Aspartic Acid diethyl ester hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Used in the synthesis of antiviral agents (e.g., adefovir dipivoxil analogues) and structural modification of peptide-based drugs | Employed as a chiral building block in coupling reactions; aspartic acid residues are introduced via hydrolysis, deprotection, and related steps |
| Organic Synthesis | Applied as a chiral auxiliary or ligand precursor in asymmetric catalytic reactions | Provides a chiral environment in Diels–Alder, alkylation, and other reactions; recovered or removed after subsequent transformations |
| Agrochemicals | Serves as a potential synthetic intermediate for chiral agrochemicals (e.g., pyrethroid derivatives) | Constructs biologically active molecules containing an aspartic acid scaffold via transesterification, amidation, and related reactions |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (D-Aspartic Acid Diethyl Ester Hydrochloride) | Acid-Base Titration | Quantifies active compound by titration with standardized NaOH using phenolphthalein indicator; endpoint corresponds to neutralization of hydrochloride salt. |
| Water Content | Karl Fischer Titration | Measures trace water via coulometric or volumetric reaction between water and iodine generated in situ from KF reagent. |
| Residual Solvents (Ethanol, Dichloromethane) | Gas Chromatography (GC-FID) | Separates and quantifies volatile organic solvents using flame ionization detection against calibrated standards. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Detects trace metal impurities by plasma ionization followed by mass spectrometric quantification at element-specific m/z ratios. |
| Chloride Content | Potentiometric Titration | Determines chloride ions using silver nitrate titrant and silver/silver chloride electrode; endpoint detected by potential inflection. |
| Optical Rotation | Polarimetry | Measures specific rotation at 20 C and 589 nm to confirm chiral integrity and enantiomeric purity of D-isomer. |
| Related Substances | HPLC-UV | Separates and quantifies structurally related impurities (e.g., monoester, free acid, L-isomer) using reversed-phase C18 column and UV detection at 210 nm. |
| pH (1% w/v aqueous solution) | pH Potentiometry | Determines acidity of aqueous solution using calibrated glass electrode and pH meter under controlled temperature. |
| Residue on Ignition | Gravimetric Analysis | Measures non-volatile inorganic residue after high-temperature ashing (700-800 C) and precise weighing. |
| Microbial Limits | Membrane Filtration | Quantifies aerobic mesophilic bacteria and molds/yeasts by filtration, membrane transfer to selective agar, and colony enumeration. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry powder particle size distribution by measuring angular scattering pattern of laser beam passing through dispersed sample. |
| Appearance (Color and Clarity) | Visual Inspection | Assesses physical state, color (white to off-white), and absence of visible particulates or cloudiness in solution or solid form. |
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 75.0-79.0°C |
| Optical Rotation | -7.4 to -8.4° (c=1, in 1M HCl) |
| Total Impurities | <=1.5% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Heavy Metals | <=20 ppm |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.