Methyl 2-iodo-5-nitrobenzoate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 112239-00-6 |
| Product name | Methyl 2-iodo-5-nitrobenzoate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methyl 2-iodo-5-nitrobenzoate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methyl 2-iodo-5-nitrobenzoate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methyl 2-iodo-5-nitrobenzoate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Pharmaceutical Intermediates | Serves as a key synthetic building block; the reactivity of the iodine atom enables biaryl bond formation—e.g., via Suzuki or Sonogashira coupling, or amination—to construct biphenyl or diaryl frameworks for bioactive molecular scaffolds. |
| Pharmaceutical Chemicals | Active Pharmaceutical Ingredient (API) Synthesis | Used in the synthesis of pyrrolo[2,1-f][1,2,4]triazine derivatives, which serve as core intermediates for VEGF receptor tyrosine kinase inhibitors (e.g., therapeutics for retinal diseases). |
| Organic Synthesis | Heterocyclic Compound Construction | Enables intramolecular or intermolecular cyclization to form fused heterocyclic systems—including indole, isoindolinone, and benzofuran—for the development of novel organic functional molecules. |
| Research Reagents | Chemical Reagent Development | Serves as a specific substrate for aromatic nucleophilic substitution reactions, supporting studies on how electron-withdrawing groups (e.g., nitro, ester) influence the reactivity and regioselectivity of haloarenes. |
Manufacturing Quality Control of Methyl 2-iodo-5-nitrobenzoate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 254 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., isomers, dehalogenated or reduced by-products) using gradient HPLC-UV. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., methanol, ethyl acetate, toluene) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine-based redox reaction in anhydrous methanol medium. |
| Heavy Metals | ICP-MS | Quantifies toxic elements (Pb, Cd, Hg, As) after acid digestion using inductively coupled plasma mass spectrometry for ultra-trace sensitivity. |
| Iodine Content | Potentiometric Titration | Measures total iodine by oxidizing iodide to iodine followed by titration with sodium thiosulfate using starch indicator or potentiometric endpoint. |
| Acid Value | Acid-Base Titration | Determines free carboxylic acid content by titration with standardized NaOH solution using phenolphthalein or potentiometric endpoint. |
| Melting Point | Capillary Melting Point Apparatus | Measures temperature range at which solid transitions to liquid, indicating purity and identity based on crystalline integrity. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of foreign particles under controlled white light against established visual standards. |
| Loss on Drying | Gravimetric Analysis | Determines volatile matter by measuring weight loss after drying at specified temperature (e.g., 105 C) under vacuum or nitrogen. |
| Chloride Impurity | Ion Chromatography | Quantifies chloride ions using suppressed conductivity detection after separation on an anion-exchange column. |
| Residual Palladium | ICP-OES | Measures palladium catalyst residue after microwave-assisted digestion using inductively coupled plasma optical emission spectrometry. |
Technical Specifications of Methyl 2-iodo-5-nitrobenzoate
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.5% (GC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Identification (NMR) | Conforms to reference spectrum |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methyl 2-iodo-5-nitrobenzoate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Methyl 2-iodo-5-nitrobenzoate
Safety Information of Methyl 2-iodo-5-nitrobenzoate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Methyl 2-iodo-5-nitrobenzoate
Industrial Methyl 2-iodo-5-nitrobenzoate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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