Tert-butyl2-(piperazin-1-yl)acetate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 112257-22-4 |
| Product name | Tert-butyl2-(piperazin-1-yl)acetate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Tert-butyl2-(piperazin-1-yl)acetate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Tert-butyl2-(piperazin-1-yl)acetate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Tert-butyl2-(piperazin-1-yl)acetate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Intermediate for synthesizing active pharmaceutical ingredients (APIs) containing a piperidine ring (e.g., NK1 receptor antagonists, 5-HT receptor modulators) | Introduced into target molecules via amidation, reductive amination, or coupling reactions in inert solvents (e.g., THF, DCM); the tert-butyl ester group is selectively cleaved under acidic conditions (e.g., TFA/DCM) to unmask the carboxylic acid functionality |
| Agrochemical R&D | Potential structural motif for agrochemical compounds, used to construct biologically active heterocyclic derivatives | Employed as a chiral building block in multistep syntheses; novel insecticidal or plant growth regulatory core scaffolds are constructed via ester hydrolysis, condensation, or cyclization reactions |
| Organic Synthesis | Multifunctional protected glycine derivative offering moderate steric hindrance at the piperidine nitrogen and tunable carboxylic acid protection | Alkylation or arylation at the 1-position nitrogen of piperidine, or selective functional group transformation leveraging orthogonal deprotection of the tert-butyl ester; commonly used in solid-phase peptide synthesis (SPPS) for constructing piperidinyl amino acid analogues |
Manufacturing Quality Control of Tert-butyl2-(piperazin-1-yl)acetate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a certified reference standard using reversed-phase chromatography and UV detection. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC with UV detection relative to the main peak. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents based on calibrated response factors. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine generation in pyridine/methanol medium to determine water by stoichiometric reaction. |
| Acid Value | Acid-Base Titration | Titration with standardized sodium hydroxide solution using phenolphthalein indicator to determine free carboxylic acid equivalents. |
| Residue on Ignition | Gravimetric Analysis | Heating sample at 700-800 C to constant weight and measuring non-volatile inorganic residue as percentage of original mass. |
| Heavy Metals | ICP-OES | Digestion followed by inductively coupled plasma optical emission spectroscopy to simultaneously quantify metals (e.g., Pb, Cd, Hg, Ni) at trace levels. |
| Chloride Content | Ion Chromatography | Separation of chloride anions on an anion-exchange column with conductivity detection and quantification against calibration standards. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific rotation using a polarimeter at 20 C with sodium D-line (589 nm) to confirm chiral integrity. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range over which solid transitions to liquid using controlled heating and visual observation. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against standard references under controlled lighting conditions. |
| pH of Aqueous Solution | pH Meter | Measurement of hydrogen ion activity in a saturated aqueous suspension using calibrated pH electrode and buffer standards. |
Technical Specifications of Tert-butyl2-(piperazin-1-yl)acetate
| Test Item | Specification |
|---|---|
| Appearance | Colorless liquid |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Refractive Index (n20/D) | 1.465–1.475 |
| Relative Density (20°C/25°C) | 0.94–0.96 g/cm³ |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Tert-butyl2-(piperazin-1-yl)acetate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Tert-butyl2-(piperazin-1-yl)acetate
Safety Information of Tert-butyl2-(piperazin-1-yl)acetate
| Pictograms |   |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Tert-butyl2-(piperazin-1-yl)acetate
Industrial Tert-butyl2-(piperazin-1-yl)acetate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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