1-Boc-hexahydro-1,4-diazepine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 112275-50-0 |
| Product name | 1-Boc-hexahydro-1,4-diazepine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-Boc-hexahydro-1,4-diazepine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-Boc-hexahydro-1,4-diazepine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-Boc-hexahydro-1,4-diazepine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a key intermediate in synthesizing active pharmaceutical ingredients (APIs) containing the 1,4-diazepane scaffold (e.g., CCR5 antagonists, kinase inhibitors) | Provides controlled release of the 1,4-diazepane moiety in coupling reactions or amine protection/deprotection strategies; commonly participates in subsequent amidation, alkylation, or cyclization reactions following tert-butoxycarbonyl (Boc) deprotection under acidic conditions (e.g., TFA/DCM) |
| Fine Chemicals | Used to prepare functionalized macrocyclic ligands and linkers for metal–organic frameworks (MOFs) | Introduces functionalized aryl groups onto nitrogen atoms via Suzuki or Ullmann coupling, followed by deprotection and coordination with metal salts to construct selective recognition or catalytic materials |
| Agrochemical R&D | Explored as a structural building block for nitrogen-containing heterocyclic agrochemical molecules | Serves as a saturated seven-membered bis-aza heterocyclic precursor with tunable basicity and steric bulk during lead optimization of insecticidal or fungicidal compounds, enabling late-stage structural modification |
Manufacturing Quality Control of 1-Boc-hexahydro-1,4-diazepine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reverse-phase HPLC with UV detection at 210–220 nm, relative to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities (e.g., residual 1,4-diazepane, di-tert-butyl dicarbonate, hydrolysis products) using gradient elution and UV detection. |
| Residual Solvents | GC-FID | Identification and quantification of solvents (e.g., THF, DCM, MeOH, EtOAc) by gas chromatography with flame ionization detection against calibrated standards. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with sample moisture. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, based on elemental mass spectrometric detection. |
| Residual Inorganic Salts (e.g., NaCl, K₂CO₃) | Ion Chromatography (IC) | Separation and quantification of anions (Cl⁻, CO₃²⁻) and cations (Na⁺, K⁺) using suppressed conductivity detection. |
| Optical Rotation | [α]D | Measurement of specific rotation using a polarimeter at 20 °C and sodium D-line (589 nm) to confirm chiral integrity and absence of racemization. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition determination via controlled heating; verifies crystallinity and batch consistency against reference material. |
| Residual tert-Butyl Carbamate | GC-MS | Targeted detection and quantification of tert-butyl carbamate (a potential degradation product) using gas chromatography coupled with mass spectrometric identification. |
| pH (10% w/v aqueous suspension) | pH Meter | Electrochemical measurement of hydrogen ion activity in a standardized aqueous suspension to assess acidic/basic impurity load. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution using Mie scattering theory to ensure uniformity for downstream processing. |
| Microbial Contamination | Membrane Filtration + Culture | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per USP <61> and <62>. |
Technical Specifications of 1-Boc-hexahydro-1,4-diazepine
| Test Item | Specification |
|---|---|
| Appearance | Yellow liquid |
| Purity | >=98.5% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Odor | Characteristic odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-Boc-hexahydro-1,4-diazepine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-Boc-hexahydro-1,4-diazepine
Packaging of 1-Boc-hexahydro-1,4-diazepine
Industrial 1-Boc-hexahydro-1,4-diazepine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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