4-Nitropyridine N-oxide Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1124-33-0 |
| Product name | 4-Nitropyridine N-oxide |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Nitropyridine N-oxide
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Nitropyridine N-oxide Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Nitropyridine N-oxide
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Pharmaceutical Intermediates | Used in the synthesis of antibacterial agents (e.g., pyridone antibiotics) or other nitrogen-containing heterocyclic drugs, serving as a key structural unit for introducing N-oxide functionality. |
| Pharmaceutical Chemicals | Drug Discovery and Screening | Serves as a pharmacophore model to investigate the role of N-oxides in drug metabolism, toxicity, and pharmacological activity. |
| Organic Synthesis | Substrate for Substitution Reactions | Leverages N-oxide activation at the α-position (2- or 4-position) to enable nucleophilic substitution for introducing amino or alkoxy groups, thereby synthesizing polysubstituted pyridine derivatives. |
| Organic Synthesis | Precursor for Deoxygenation Reactions | Undergoes deoxygenation (e.g., using phosphorus or sulfur reagents or metal catalysts) to produce 4-nitropyridine. |
| Analytical Chemistry | Reagent | Serves as an organic synthetic intermediate for preparing specialized analytical reagents or labeled compounds. |
| Research Chemicals | Chemical Reagent | Used in laboratory-scale studies of heterocyclic chemistry, reaction mechanism investigation, and catalyst performance evaluation. |
Manufacturing Quality Control of 4-Nitropyridine N-oxide
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification Test | Infrared Spectroscopy (IR) | Determines the infrared absorption spectrum of the sample and compares it with a reference spectrum to confirm the presence of characteristic functional groups of 4-nitropyridine N-oxide (e.g., N→O, nitro groups) based on matching absorption peaks. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Utilizes nuclear magnetic resonance technology to analyze chemical shifts and coupling constants of hydrogen atoms in the molecule, helping verify structural features and supporting identification. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase C18 column with a mobile phase consisting of water and organic solvents (e.g., methanol or acetonitrile) at appropriate ratios. Detection is performed using a UV detector (typically at 254 nm or around 300 nm). Quantification is carried out via external standard or internal standard method to determine the main component content. |
| Ultraviolet-Visible Spectrophotometry (UV-Vis) | Leverages the characteristic absorption of 4-nitropyridine N-oxide at specific wavelengths (e.g., approximately 300–350 nm). Concentration is determined using a standard curve method, suitable for rapid quantification of high-purity samples. | |
| Related Substances (Impurity Testing) | High-Performance Liquid Chromatography (HPLC) | Employs gradient or isocratic elution to separate the main peak from potential impurities (such as unreacted starting materials, by-products, degradation products, etc.). Impurity levels are calculated using area normalization or the principal component self-control method with correction factors. |
| Drying Loss | Thermogravimetric Analysis (TGA) or Constant Weight Method | Dries the sample at a specified temperature (e.g., 105°C) until constant weight is achieved, measuring mass loss to assess moisture and volatile substance content. |
| Melting Point Determination | Capillary Melting Point Method or Digital Melting Point Apparatus | Measures the temperature range from initial melting to complete melting, comparing results with literature values (approximately 158–162°C) to evaluate purity and consistency. |
| Residual Solvents | Gas Chromatography (GC) | Uses headspace injection or direct injection combined with FID detection to identify and quantify residual organic solvents (e.g., methanol, ethanol, dichloromethane) from synthesis or purification processes, ensuring compliance with pharmacopoeial or ICH guidelines regarding permissible limits. |
| Heavy Metals / Elemental Impurities | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) | After sample digestion, measures concentrations of harmful elements such as lead, arsenic, cadmium, and mercury to ensure compliance with safety standards (e.g., ICH Q3D). |
Technical Specifications of 4-Nitropyridine N-oxide
| Test Item | Specification |
|---|---|
| Appearance | Light yellow to amber crystalline powder |
| Purity | >=98.0% (HPLC) |
| Melting Point | 126–129°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Nitropyridine N-oxide
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Nitropyridine N-oxide
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Industrial 4-Nitropyridine N-oxide Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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