Pioglitazone hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 112529-15-4 |
| Product name | Pioglitazone hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Pioglitazone hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Pioglitazone hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Pioglitazone hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Treatment of type 2 diabetes; insulin sensitizer for improving insulin resistance | Manufactured as an active pharmaceutical ingredient (API) via solid-phase synthesis; key steps include construction of the thiazolidinedione ring and introduction of the pyridyl group, followed by crystallization-based purification to yield drug substance meeting pharmacopoeial specifications |
Manufacturing Quality Control of Pioglitazone hydrochloride
| Test Item | Common Testing Method | Method Description |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | Confirm the characteristic functional group structure by comparing the sample's IR absorption spectrum with that of a reference or standard spectrum. |
| High-Performance Liquid Chromatography (HPLC) | Under specific chromatographic conditions, compare the retention time of the main peak between the test sample and the reference sample to confirm consistency. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use reverse-phase HPLC with a C18 column as the stationary phase and a UV detector (typically at wavelengths of 230–270 nm), employing an external standard method to determine the content of the main component. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Separate and quantitatively analyze process-related impurities and degradation products using gradient or isocratic elution programs. Typically use area normalization or the main component self-comparison method with correction factors. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace injection or direct injection with an FID detector to detect residual organic solvents such as methanol, ethanol, and dichloromethane according to pharmacopoeia requirements. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Conventional Drying Method | Dry the sample under specified temperature (e.g., 105°C) until constant weight is achieved, then calculate the percentage of weight loss to assess moisture and volatile matter content. |
| Ignition Residue | High-Temperature Incineration Method | Weigh the inorganic residue remaining after incinerating the sample at high temperatures (typically 700–800°C) to control inorganic impurities. |
| Heavy Metals | Atomic Absorption Spectrophotometry (AAS) or ICP-MS | Determine the content of heavy metal elements such as lead, cadmium, mercury, and arsenic using atomic absorption or inductively coupled plasma mass spectrometry. |
| pH Value | pH Meter Method | Determine the acidity or alkalinity by measuring the pH of a solution of defined concentration using a calibrated pH meter. |
| Dissolution (for Dosage Forms) | Dissolution Test (Paddle or Basket Method) | Measure drug dissolution over time in a specified medium (e.g., pH 6.8 phosphate buffer) using HPLC or UV methods. |
| Crystal Form (if applicable) | X-ray Powder Diffraction (XRPD) | Analyze the crystal form of the drug using X-ray diffraction patterns to ensure crystal form consistency, which affects stability and bioavailability. |
Technical Specifications of Pioglitazone hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.5% (LC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 127°C - 131°C |
| Identification (NMR) | Consistent with reference standard |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Pioglitazone hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Pioglitazone hydrochloride
Packaging of Pioglitazone hydrochloride
Industrial Pioglitazone hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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