1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 112811-72-0 |
| Product name | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 112811-72-0
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 112811-72-0 Supplier from China
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Industrial Applications of 112811-72-0
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of antibacterial drug intermediates for fluoroquinolone antibiotics (e.g., gatifloxacin) | Used as a key intermediate in multi-step organic synthesis, building the quinolone core structure via acylation, condensation, and related processes |
Manufacturing Quality Control of 112811-72-0
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Reverse-phase C18 column is used, with phosphate buffer (pH approximately 2.5–3.0) and acetonitrile or methanol as the mobile phase for gradient or isocratic elution. The UV detector is set at around 278 nm to detect the main peak area, and content is calculated by external standard method. This method offers strong specificity and good reproducibility, suitable for quantitative analysis of active pharmaceutical ingredients (APIs) and dosage forms. |
| Related Substances (Impurity) Testing | High-Performance Liquid Chromatography (HPLC) | Same conditions as content determination or optimized gradient programs are applied to detect possible synthetic intermediates and degradation products (e.g., demethylated impurities, oxidized products). Impurity levels are assessed by comparison with reference standards or using self-control methods (area normalization or limit-based impurity testing), evaluating total impurities and individual impurity concentrations. |
| Identification Test | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Ultraviolet absorption spectra are measured in 0.1 mol/L hydrochloric acid or aqueous solution. Characteristic absorption peaks typically appear near 278 nm and 325 nm, compared with standard spectra for preliminary identification. |
| Identification Test | Fourier Transform Infrared Spectroscopy (FT-IR) | Sample is mixed with KBr and pressed into a pellet; infrared absorption spectrum is recorded and compared with reference or standard spectra to confirm consistency of key functional group peaks (e.g., carboxyl, carbonyl, aromatic ring, C-F bond). |
| Moisture Content | Karl Fischer Titration | Water content is determined using coulometric or volumetric Karl Fischer titration, particularly suitable for controlling loss on drying or residual solvent effects in raw materials. Moisture must be within specified limits (typically ≤1.0%). |
| Residual Solvents | Gas Chromatography (GC) | Capillary columns (e.g., DB-624 or PEG columns) are used with nitrogen as carrier gas and FID detection. This method detects organic solvents potentially remaining from manufacturing processes (e.g., methanol, ethanol, acetone, dichloromethane, N,N-dimethylformamide), controlled according to ICH Q3C guidelines. |
| Polymorph Analysis | X-Ray Powder Diffraction (XRPD) | Crystal structure features are analyzed through characteristic diffraction peaks to identify polymorphic forms and ensure batch-to-batch consistency of crystal form, which affects solubility and stability. |
| Particle Size Distribution | Laser Diffraction Analysis (LDI) | Particles are dispersed via wet or dry methods to determine particle size distribution (e.g., D10, D50, D90). This significantly influences dissolution rate and bioavailability of formulations. |
| Heavy Metal Testing | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Quantifies trace heavy metals such as lead, cadmium, mercury, and arsenic. Results must comply with pharmacopeial requirements for elemental impurities (per ICH Q3D). Samples usually require digestion prior to analysis. |
| Bacterial Endotoxins / Microbial Limits | Dynamic Turbidity Method (LAL assay) or Culture-Based Method | For injectable-grade raw materials, bacterial endotoxin levels are tested (limit generally <0.5 EU/mg); non-sterile raw materials require testing for aerobic microorganisms, molds, and control organisms (e.g., Escherichia coli), meeting pharmacopeial microbial limits requirements. |
Technical Specifications of 112811-72-0
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 228–232°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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| Lot/Batch Number | *Required fields | |
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Industrial 112811-72-0 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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