Fmoc-Met-OH Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 112883-40-6 |
| Product name | Fmoc-Met-OH |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-Met-OH
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-Met-OH Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-Met-OH
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Protective amino acid monomer for peptide synthesis, used to construct peptide drugs containing D-methionine residues | Used in solid-phase peptide synthesis (SPPS) under the Fmoc strategy as a D-configured methionine derivative for N-terminal α-amino protection and coupling reactions |
| Biochemical Research | Studying the role of D-amino acids in peptide structure and function, including enzyme stability and receptor selectivity | Integrated into standard Fmoc-SPPS protocols on automated or manual peptide synthesizers, coupled sequentially with other Fmoc-amino acids |
| Drug Development | Synthesis of metabolically stable peptide candidates with enhanced resistance to proteolytic degradation | Fmoc-D-methionine is incorporated during peptide chain assembly to replace the L-configured counterpart, thereby extending the in vivo half-life of the target molecule |
Manufacturing Quality Control of Fmoc-Met-OH
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies Fmoc-D-Met content by UV absorbance at 268 nm using a reversed-phase C18 column and calibrated standard. |
| Chiral Purity | Chiral HPLC | Separates D- and L-enantiomers on a chiral stationary phase; D-isomer peak area is compared to total methionine-related peaks. |
| Water Content | Karl Fischer Titration | Measures water via coulometric or volumetric titration with iodine, based on the stoichiometric reaction of water with iodine and sulfur dioxide. |
| Residual Solvents | GC-FID | Detects and quantifies common solvents (e.g., DMF, dichloromethane) using flame ionization detection after capillary column separation. |
| Heavy Metals | ICP-MS | Quantifies trace metal impurities (e.g., Pb, Cd, Ni) by plasma ionization followed by mass spectrometric detection. |
| Residual Chloride | Ion Chromatography | Separates and quantifies chloride ions using an anion-exchange column and suppressed conductivity detection. |
| Related Substances | HPLC-UV | Identifies and quantifies structurally related impurities (e.g., Fmoc-Met-OH, deprotected Met, oxidation products) using gradient elution. |
| Optical Rotation | [alpha]D Measurement | Determines specific rotation at 589 nm using a polarimeter; confirms chiral integrity and batch consistency. |
| pH (1% w/v aqueous solution) | pH Meter | Measures hydrogen ion activity in a standardized aqueous suspension using calibrated glass electrode. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of foreign particles under controlled white light against standard reference. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated digital apparatus per USP <741>. |
| Loss on Drying | Gravimetric Analysis | Measures volatile content by weight loss after drying under specified vacuum and temperature conditions. |
Technical Specifications of Fmoc-Met-OH
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (LC-MS) |
| Optical Rotation | +27.0 to +33.0 deg (c=1, in DMF) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-Met-OH
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-Met-OH
Packaging of Fmoc-Met-OH
Industrial Fmoc-Met-OH Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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