tert-butyl 3-Methylenepyrrolidine-1-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 114214-71-0 |
| Product name | tert-butyl 3-Methylenepyrrolidine-1-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for tert-butyl 3-Methylenepyrrolidine-1-carboxylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk tert-butyl 3-Methylenepyrrolidine-1-carboxylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of tert-butyl 3-Methylenepyrrolidine-1-carboxylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Organic synthesis intermediate | Used as a protected pyrrolidine derivative to construct complex drug molecule scaffolds |
| Chemical Research | Synthesis of pyrrolidine compounds | Applied in multistep syntheses to introduce methylene structural units, enabling cyclization or coupling reactions |
| Biopharmaceuticals | Prodrug design and development | Employed with BOC protecting groups to control reaction selectivity and achieve site-specific functional group transformation |
Manufacturing Quality Control of tert-butyl 3-Methylenepyrrolidine-1-carboxylate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210-220 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3B. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection for quantitative analysis of common solvents (e.g., acetone, THF, methanol) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific rotation using a polarimeter at 20-25 C and sodium D-line (589 nm) to confirm chiral integrity and enantiomeric purity. |
| Heavy Metals | ICP-MS | Quantitative multi-element analysis after acid digestion; detection at sub-pptr levels using mass spectrometry with internal standard correction. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using suppressed conductivity detection with anion-exchange column and carbonate/bicarbonate eluent. |
| Residue on Ignition | Gravimetric Analysis | Ignition at 700-800 C followed by weighing of non-volatile inorganic residue to assess inorganic ash content. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement using calibrated capillary apparatus per USP <741>, reporting onset and range. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against established reference under controlled lighting and against white/black backgrounds. |
| pH of Aqueous Solution | pH Meter | Measurement of pH in a defined aqueous suspension or solution (e.g., 1% w/v) using calibrated pH electrode per USP <791>. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder via laser scattering to determine D10, D50, D90 values according to ISO 13320. |
Technical Specifications of tert-butyl 3-Methylenepyrrolidine-1-carboxylate
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Odor | Characteristic mild odor |
| Optical Rotation | +12.0° to +16.0° (c=1, CHCl3) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of tert-butyl 3-Methylenepyrrolidine-1-carboxylate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of tert-butyl 3-Methylenepyrrolidine-1-carboxylate
Safety Information of tert-butyl 3-Methylenepyrrolidine-1-carboxylate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of tert-butyl 3-Methylenepyrrolidine-1-carboxylate
Industrial tert-butyl 3-Methylenepyrrolidine-1-carboxylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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