N-Cbz-L-Serine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1145-80-8 |
| Product name | N-Cbz-L-Serine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Cbz-L-Serine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Cbz-L-Serine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Cbz-L-Serine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a protected derivative of L-serine for amino-group protection in peptide synthesis | Applied in solid-phase or liquid-phase peptide synthesis (SPPS/LPPS); the α-amino group is protected with a benzyloxycarbonyl (Cbz) group to suppress side reactions, and the protecting group is subsequently removed via hydrogenolysis or acidolysis |
| Biochemical Research | Served as a synthetic intermediate in enzymology studies and protein structure–function analysis | Used as a building block in custom peptide synthesis to investigate the role of serine residues in enzyme active sites |
| Organic Synthesis | Employed as a chiral synthon or intermediate for constructing complex molecules | Introduces the serine backbone in asymmetric synthesis; the Cbz group provides stability and enables selective deprotection |
Manufacturing Quality Control of N-Cbz-L-Serine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase chromatography with UV detection at 210 nm based on peak area comparison to reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities using gradient elution and UV detection, with identification/quantification against reference standards or threshold limits. |
| Water Content | Karl Fischer Titration | Determines water by coulometric or volumetric titration using iodine generated electrochemically or added reagent, reacting stoichiometrically with water. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic ash content by ignition at 700-800 C followed by weighing of residual non-volatile matter. |
| Heavy Metals | ICP-OES | Quantifies Pb, Cd, Hg, As, and other regulated metals via plasma excitation and elemental emission spectroscopy after acid digestion. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column with conductivity detection, calibrated against NaCl standards. |
| Specific Optical Rotation | Polarimetry | Measures rotation of plane-polarized light at 20 C using sodium D-line (589 nm) to confirm chiral integrity and enantiomeric purity. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Determines hydrogen ion activity in a 1% w/v aqueous solution using calibrated glass electrode and pH meter. |
| Loss on Drying | Thermogravimetric Analysis | Quantifies volatile components (e.g., solvents, moisture) by weight loss upon heating at 105 C for 2 hours under controlled atmosphere. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary tube method per USP <741>. |
| Residual Solvents | GC-FID | Identifies and quantifies residual manufacturing solvents (e.g., methanol, ethyl acetate) by gas chromatography with flame ionization detection. |
| Microbial Contamination | Membrane Filtration and Plate Count | Detects and enumerates aerobic microorganisms using filtration, membrane transfer to agar media, and colony enumeration after incubation. |
Technical Specifications of N-Cbz-L-Serine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 148-152°C |
| Optical Rotation | +5.6 to +6.6 (c=1, in 1N HCl) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Cbz-L-Serine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Cbz-L-Serine
Packaging of N-Cbz-L-Serine
Industrial N-Cbz-L-Serine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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