5-Iodocytidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1147-23-5 |
| Product name | 5-Iodocytidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Iodocytidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Iodocytidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Iodocytidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Antiviral drug intermediate | Prepared via selective iodination of cytidine with an iodinating reagent (e.g., N-iodosuccinimide) under basic conditions |
| Pharmaceutical R&D | Nucleoside analogs for oncology research | Used as thymidine kinase substrate analogs in in vitro cytotoxicity screening and antitumor mechanism studies |
| Biochemistry | Radiolabeled precursor (e.g., for synthesis of ¹²⁵I-5-iodocytidine) | Radiolabeled iodine introduced via isotopic exchange or chemical synthesis for molecular imaging and tracer studies |
| Medicinal Chemistry | Template molecule for nucleoside analog structural modification | Used to synthesize derivatives with enhanced antiviral activity or metabolic stability through C-5 functionalization |
Manufacturing Quality Control of 5-Iodocytidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies 5-iodocytidine by reversed-phase HPLC separation and UV absorbance detection at ~280 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., cytidine, iodinated by-products) using gradient HPLC with UV detection and relative response factors. |
| Residual Solvents | GC-FID | Measures residual solvents (e.g., methanol, acetonitrile, ethyl acetate) by gas chromatography with flame ionization detection against calibrated standards. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine generation in pyridine-free reagents; based on stoichiometric reaction with water. |
| Heavy Metals | ICP-MS | Quantifies trace heavy metals (Pb, Cd, Hg, As, Ni) after acid digestion by inductively coupled plasma mass spectrometry with isotope dilution for high sensitivity. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic ash content by ignition at 700-800 C and weighing the non-volatile residue after cooling in a desiccator. |
| Optical Rotation | Polarimetry | Determines specific optical rotation using sodium D-line light (589 nm) to confirm chiral integrity and identity of the D-ribofuranosyl configuration. |
| pH of Solution | Potentiometric pH Measurement | Measures hydrogen ion activity in a 1% w/v aqueous solution using a calibrated glass electrode pH meter. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry powder particle size distribution by measuring angular variation in laser light scattering intensity. |
| Microbial Contamination | Membrane Filtration | Detects aerobic microorganisms by filtering sample solution through a sterile membrane, then incubating on TSA agar and counting colony-forming units. |
| Endotoxins | Kinetic Chromogenic LAL Assay | Quantifies bacterial endotoxins via Limulus amebocyte lysate enzymatic cascade that cleaves a chromogenic substrate, measured kinetically at 405 nm. |
| Identity Confirmation | FTIR Spectroscopy | Verifies molecular structure by matching characteristic functional group absorption bands (e.g., C=O, C-I, O-H) in the mid-infrared spectrum to a reference standard. |
Technical Specifications of 5-Iodocytidine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 210–214°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Optical Rotation | -15° to -19° (c=1, in water) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Iodocytidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Iodocytidine
Packaging of 5-Iodocytidine
Industrial 5-Iodocytidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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