5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 114745-26-5 |
| Product name | 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 5KG/bag25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Synthesis of nucleoside analogs for antiviral and anticancer drugs | Organic synthesis introducing a DMT group at the 5′-O position, an isobutyryl group at the N2 position, and a methyl group at the 2′-O position of guanosine |
| Nucleic Acid Chemistry | Intermediate for RNA or DNA strand synthesis to construct modified nucleotides | Used as a starting material in solid-phase synthesis to prepare specifically modified oligonucleotides |
| Research | Biochemical and molecular biology studies, including probe design and functional analysis | Chemically incorporated into nucleic acid molecules to investigate structure–function relationships |
Manufacturing Quality Control of 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at 260 nm, calibrated against certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of structurally related impurities using gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents per ICH Q3C. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content. |
| Heavy Metals | ICP-MS | Inductively coupled plasma mass spectrometry for simultaneous quantification of elemental impurities (e.g., Pb, Cd, As, Hg) per ICH Q3D. |
| Residual Chloride | Ion Chromatography | Separation and quantification of chloride ions using suppressed conductivity detection. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific optical rotation using a polarimeter at 20 C and sodium D-line (589 nm) to confirm stereochemical integrity. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating crystallinity and purity. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample using light scattering to determine size distribution profile. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and detection of specified pathogens per USP <61> and <62>. |
| Residual DMTr Group | HPLC-UV | Specific assay for unreacted or cleaved DMT moiety using acidic hydrolysis followed by HPLC-UV quantification. |
| pH of Solution | Potentiometric pH Measurement | Electrochemical measurement of hydrogen ion activity in aqueous solution prepared at defined concentration. |
Technical Specifications of 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (by LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Conforms to reference standard |
| Optical Rotation | -15.0° to -19.0° (c=1, in pyridine) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine
Safety Information of 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine
Industrial 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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