tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1147557-97-8 |
| Product name | tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Reagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate in the synthesis of targeted therapeutics (e.g., BRD4 inhibitors) | Organic synthesis, chiral resolution, crystallization-based purification |
| Research & Development | Construction of spirocyclic motifs for exploration of novel bioactive molecules | Molecular structure modification, structure–activity relationship (SAR) studies, biological activity screening |
Manufacturing Quality Control of tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
| Milestone Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection, Melting Point Determination | Observe sample color and physical state (typically white to off-white solid). Determine melting point range (literature value approximately 85–92 °C) to assess purity and crystallinity. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with gradient elution of water-acetonitrile or methanol, and UV detection (210–230 nm) for quantification of the main component. Calculate content using external standard or internal standard method; typically requires ≥98.0%. |
| Related Substances | High-Performance Liquid Chromatography (HPLC) | Same conditions as content determination, but with lower detection wavelength (e.g., 200 nm) and extended run time to detect degradation products (e.g., de-tert-butyl product, oxidized species, hydrolysis products). Control individual impurities ≤0.1% and total impurities ≤0.5% using area normalization or reference standard method. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with DB-624 or HP-INNOWAX columns and FID detection. Detect common solvents such as methanol, ethanol, ethyl acetate, dichloromethane, and THF according to ICH Q3C guidelines, ensuring levels are within PDE limits. |
| Water Content | Karl Fischer Titration | Quantify trace moisture using iodine-sulfur dioxide-pyridine system via volumetric or coulometric Karl Fischer titration. Control water content ≤0.5% (may be relaxed to 1.0% depending on process requirements). |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After ashing or microwave digestion, determine levels of heavy metals such as lead, cadmium, mercury, and arsenic. Comply with ICH Q3D or pharmacopoeial limits (e.g., Pb ≤5 ppm). |
| UV-Visible Absorption Spectroscopy (UV-Vis) | UV Spectrophotometry | Scan in the 200–400 nm range to confirm characteristic absorption peaks (e.g., λmax ≈ 215 nm), used for preliminary identification and impurity screening, excluding strong UV-absorbing impurities. |
| Nuclear Magnetic Resonance Spectroscopy (¹H NMR / ¹³C NMR) | Nuclear Magnetic Resonance (NMR) Spectroscopy | Use DMSO-d₆ or CDCl₃ as solvent to analyze proton and carbon spectra. Confirm structural features (e.g., tert-butyl singlet at δ ≈ 1.45 ppm, bridgehead proton signals, hydroxyl proton at δ ≈ 3.5–4.5 ppm) for structure confirmation and impurity identification. |
| Chiral Purity (if applicable) | Chiral HPLC or SFC | Use chiral stationary phase columns (e.g., Chiralpak AD-H, OD-H) to separate enantiomers and detect potential optical isomer impurities. Control enantiomeric excess (ee) ≥99% (if applicable to chiral intermediates). |
| Solubility | Shaking Flask Method | Determine solubility in water, ethanol, ethyl acetate, DMSO, etc., to assess suitability for formulation development and assist in process design. |
Technical Specifications of tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 112–116°C |
| Identification (NMR) | Conforms to reference spectrum |
| Optical Rotation | +15.0 to +19.0° (c=1, CHCl₃) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
Safety Information of tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
Industrial tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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