tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 114772-40-6 |
| Product name | tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for synthesizing angiotensin II receptor blockers (e.g., valsartan) | Undergoes nucleophilic substitution with corresponding amines under basic conditions to construct the biphenyltetrazole moiety of valsartan; followed by deprotection, hydrolysis, and other steps to complete API synthesis |
| Pharmaceutical R&D | Used to build compound libraries featuring biphenyl scaffolds | Enables structural diversification via palladium-catalyzed coupling, ester group transformation, or derivatization of the bromomethyl functional group for structure–activity relationship studies |
| Fine Chemicals | High-purity organic synthesis building block | Reacted with nucleophiles such as Grignard reagents, cyanides, or thiolates to prepare various functionalized biphenyl derivatives |
Manufacturing Quality Control of tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, physical state (e.g., white to pale white crystalline powder) and presence of foreign matter under natural light or standard illumination. |
| Identification | Infrared Spectroscopy (IR) Nuclear Magnetic Resonance (¹H NMR) |
IR: Compare characteristic functional group absorption peaks (e.g., ester carbonyl, aromatic ring, C–Br bond); ¹H NMR: Confirm characteristic proton chemical shifts and integration ratios to verify molecular structure. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column, with methanol/water or acetonitrile/water as the mobile phase, and UV detection (e.g., 254 nm) for quantitative determination of the main component. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Same conditions as content determination or gradient elution program to separate and quantify potential impurities (e.g., starting material residues, de-bromination products, hydrolysis products). |
| Residual Solvents | Gas Chromatography (GC) | Headspace injection or direct injection, with FID detector, to detect residual organic solvents (e.g., dichloromethane, toluene, DMF) during synthesis according to ICH Q3C guidelines. |
| Moisture | Karl Fischer Method (Karl Fischer) | Determine moisture content using volumetric or coulometric methods to ensure compliance with loss on drying requirements. |
| Melting Point | Melting Point Apparatus | Determine the melting temperature range using capillary method or digital melting point apparatus, as an auxiliary indicator of purity and crystal form. |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) |
Determine heavy metal impurities such as lead, cadmium, mercury, and arsenic after sample digestion, in accordance with ICH Q3D limits for elemental impurities. |
| Specific Rotation (if applicable) | Polarimeter | If the compound has chiral centers (usually not present in this compound), measure specific rotation to confirm optical purity. |
Technical Specifications of tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 78–82°C |
| Identification (NMR) | Conforms to reference spectrum |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
Safety Information of tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
Industrial tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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