1-Boc-3-(cyanomethylene)azetidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1153949-11-1 |
| Product name | 1-Boc-3-(cyanomethylene)azetidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-Boc-3-(cyanomethylene)azetidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-Boc-3-(cyanomethylene)azetidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-Boc-3-(cyanomethylene)azetidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a synthetic intermediate in the preparation of nitrogen-containing heterocyclic drug molecules, particularly as a precursor to β-lactam antibiotics or protease inhibitors | Serves as a key building block in multistep organic synthesis, participating in cyclization, substitution, or coupling reactions to construct complex molecular frameworks |
| Agricultural Chemicals | Potentially employed in the synthesis of bioactive nitrogen-containing heterocyclic pesticide compounds | Functions as a structural unit for introducing cyano and tert-butoxycarbonyl (Boc) protecting groups, enabling subsequent functional group transformations |
| Fine Chemicals | Applied in the synthesis of high-value nitrogen-containing heterocyclic functional materials or ligands | Undergoes fine synthetic operations—including nucleophilic addition, deprotection, or metal-catalyzed coupling—under inert atmosphere |
Manufacturing Quality Control of 1-Boc-3-(cyanomethylene)azetidine
| Detection Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Utilizes a C18 reversed-phase column with gradient elution using acetonitrile-water (containing 0.1% formic acid or trifluoroacetic acid) as the mobile phase, and UV detection (210–220 nm). The main component content is calculated via area normalization or external standard method, evaluating total impurities and levels of individual impurities. |
| Residual Solvents | Gas Chromatography (GC) | Uses headspace injection or direct injection with DB-624 or HP-INNOWAX capillary columns and FID detection. Follows ICH Q3C guidelines to determine residual levels of common organic solvents such as methanol, ethanol, acetonitrile, dichloromethane, and THF. |
| Water Content | Karl Fischer Titration | Employs Coulometric or Volumetric Karl Fischer reagents to precisely measure trace water content, ensuring compliance with pharmaceutical standards (typically ≤0.5%). Suitable for moisture-sensitive azetidine-containing compounds. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After microwave digestion, determines levels of heavy metals such as lead, cadmium, mercury, arsenic, and copper, meeting ICH Q3D or pharmacopoeial limits (e.g., Pb ≤ 10 ppm). |
| Structural Confirmation | Nuclear Magnetic Resonance Spectroscopy (¹H NMR and ¹³C NMR) | Performs proton and carbon NMR spectra in deuterated DMSO or CDCl₃, comparing characteristic peaks (e.g., cyano-methylene =CH–CN at δ 6.8–7.2 ppm, tert-butyl singlet at ~1.5 ppm, azetidine ring protons at δ 2.5–4.0 ppm) to confirm molecular structure and stereochemistry. |
| IR Spectral Identification | Fourier Transform Infrared Spectroscopy (FT-IR) | Measures infrared absorption spectra of solid samples or in ATR mode to identify key functional groups—such as nitrile (–C≡N, ~2240 cm⁻¹), ester carbonyl (C=O, ~1730 cm⁻¹), and characteristic absorptions of the azetidine ring—for qualitative identification. |
| Melting Point | Melting Point Apparatus | Determines melting point range (literature value approximately 65–70°C) as a physical property control parameter to assess crystalline form consistency and purity. |
| Appearance and Color | Visual Inspection + Colorimetry | Checks whether the solid appears as white to off-white crystalline powder with no visible foreign particles; color may be quantitatively assessed using a colorimeter (e.g., L*a*b* values) to monitor oxidation or degradation. |
| Related Substances (Impurity Profile) | HPLC-MS Coupling | Combines HPLC with mass spectrometry detection (ESI-MS) to characterize impurities beyond the main peak, enabling structural elucidation of potential degradation products (e.g., ring-opened acids), deprotection byproducts, polymers, or isomers. Ensures impurities remain within acceptable limits (e.g., single impurity ≤0.5%, total impurities ≤1.0%). |
| Chiral Purity (if applicable) | Chiral HPLC or SFC | If the synthetic route may generate chiral isomers, enantiomers are separated using chiral stationary phases (e.g., Chiralpak AD-H) or Supercritical Fluid Chromatography (SFC), and enantiomeric excess (ee value) is determined. |
Technical Specifications of 1-Boc-3-(cyanomethylene)azetidine
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 78–82°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-Boc-3-(cyanomethylene)azetidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-Boc-3-(cyanomethylene)azetidine
Safety Information of 1-Boc-3-(cyanomethylene)azetidine
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 1-Boc-3-(cyanomethylene)azetidine
Industrial 1-Boc-3-(cyanomethylene)azetidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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