5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 115473-15-9 |
| Product name | 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 115473-15-9
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 115473-15-9 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 115473-15-9
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Key intermediate in the synthesis of the antiplatelet drug ticagrelor | Prepared via multi-step organic synthesis (e.g., cyclization, acylation, hydrochloride salt formation) for subsequent construction of the ticagrelor molecular core structure |
Manufacturing Quality Control of 115473-15-9
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Characteristics | Visual inspection, microscope observation | Observe color, crystal form, and homogeneity of solid powder, which should appear as a white to off-white crystalline powder with no visible foreign particles. The hydrochloride salt should show no hygroscopicity or caking. |
| Identification Test | Infrared Spectroscopy (IR), High-Performance Liquid Chromatography (HPLC) retention time comparison, Nuclear Magnetic Resonance (¹H-NMR) | IR: Compare characteristic absorption peaks with reference spectrum (e.g., C=O stretching vibration ~1680 cm⁻¹, N–H ~3200 cm⁻¹); HPLC: Retention time matches that of reference standard under identical chromatographic conditions; NMR: Confirm chemical shifts corresponding to thiophene ring, pyridinone ring, and protonation site of the hydrochloride salt. |
| Content Determination (Main Component) | High-Performance Liquid Chromatography (HPLC-UV) | Use C18 column, gradient elution with buffer salt (e.g., phosphate buffer)-acetonitrile mobile phase, UV detection at 210–254 nm, quantification by external standard method, requiring content ≥98.0%. |
| Related Substances (Impurity Profile) | HPLC-UV or HPLC-MS | Gradient elution for separation of degradation impurities (e.g., ring-opened products, oxidized species, dehydration products, unreacted starting materials). Detection at 220 nm; individual impurity ≤0.1%, total impurities ≤0.5% (per ICH Q3B). Mass spectrometry may be used for structural identification of unknown impurities. |
| Residual Solvents | Gas Chromatography (GC-FID) | Per ICH Q3C, detect common organic solvent residues such as methanol, ethanol, acetone, ethyl acetate, dichloromethane. Use headspace injection with internal standard quantification, conforming to specified acceptance limits. |
| Water Content (Karl Fischer) | Karl Fischer Titration (Volumetric or Coulometric Method) | Determine combined and free water content. Due to hygroscopic nature of the hydrochloride salt, moisture content is typically required to be ≤1.0% (w/w) to ensure stability. |
| Heavy Metals and Elemental Impurities | ICP-MS or ICP-OES | Detect Class I elements (e.g., As, Cd, Hg, Pb) and Class II elements (e.g., Cu, Ni, Zn). Control levels within PDE (Permitted Daily Exposure) limits as per ICH Q3D. |
| Chloride Ion (Hydrochloride Salt Confirmation) | Ion Chromatography (IC) or Precipitation Titration | Determine chloride ion content via ion chromatography or silver nitrate titration. Calculate chloride content to verify it matches theoretical value (~13.2% Cl⁻ based on molecular weight calculation). |
| pH Value (Solution) | pH Meter Measurement | Prepare a 1% aqueous solution and measure pH. The hydrochloride salt typically exhibits acidic character, with a pH range of 2.5–4.5, reflecting complete salt formation. |
| Particle Size Distribution | Laser Diffraction or Microscopy | If used as an intermediate in oral solid dosage forms, particle size distribution must be controlled to ensure solubility and blend uniformity. A common requirement is D90 ≤100 μm. |
| Microbial Limits | Plate Count Method (USP/EP) | Test for total aerobic bacteria count, mold and yeast, and Escherichia coli. Applicable to non-sterile active pharmaceutical ingredients, meeting pharmacopeial limits (e.g., ≤10³ CFU/g). |
Technical Specifications of 115473-15-9
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 178–182°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
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Industrial 115473-15-9 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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