2-AMINO-3-FLUOROBENZONITRILE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 115661-37-5 |
| Product name | 2-AMINO-3-FLUOROBENZONITRILE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeReagent GradeCosmetic GradeFood Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-AMINO-3-FLUOROBENZONITRILE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-AMINO-3-FLUOROBENZONITRILE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-AMINO-3-FLUOROBENZONITRILE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of pharmaceutical intermediates | Prepared via organic synthesis methods, such as nucleophilic substitution and coupling reactions |
| Agrochemicals | Synthesis of agrochemical intermediates | Used as fluorinated aromatic nitriles, serving as functional groups in agrochemical molecular structures |
| Fine Fragrances | Synthesis of fragrance intermediates | Applied in the synthesis of aromatic compounds with specific odor profiles |
| Polymers & Advanced Materials | Synthesis of functional monomers | Employed as a fluorinated monomer in polymer synthesis to enhance material properties |
| Analytical Reagents | Preparation of standard solutions or use as a reaction reagent | Utilized in chemical analysis and laboratory research |
Manufacturing Quality Control of 2-AMINO-3-FLUOROBENZONITRILE
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Form | Visual Inspection, Melting Point Determination | Observe sample color and state (typically white to off-white crystalline powder), and determine melting point range (literature value approximately 105–110°C) to assess compliance with standard physical properties. |
| Assay (Active Ingredient) | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with acetonitrile-water (containing 0.1% formic acid or phosphate buffer) as the mobile phase. Detection is performed using a UV detector (wavelength 254 nm or 280 nm). The assay is quantified by external standard method, offering high precision and strong specificity. |
| Related Substances (Impurity Profile) | HPLC with Gradient Elution | Gradient elution is employed to separate potential impurities such as starting materials, intermediates, and degradation products (e.g., defluorinated compounds, dimers, oxidized species). Detection limits can reach 0.05%–0.1%, meeting the requirements of ICH Q3B guidelines. |
| Fluorine Content | Ion Chromatography (IC) or Fluoride Ion-Selective Electrode | After alkaline hydrolysis or oxygen flask combustion, fluoride ions are released from the sample and quantified using ion chromatography or a fluoride ion-selective electrode, ensuring fluorine content matches the theoretical value (theoretical F% ≈ 11.8%). |
| Residual Solvents | Gas Chromatography (GC-FID/MS) | In accordance with ICH Q3C guidelines, headspace or direct injection GC is used to detect common organic solvents such as ethanol, acetone, acetonitrile, and DMF. Residual levels must comply with pharmaceutical limits (e.g., acetonitrile ≤ 410 ppm). |
| Moisture Content | Karl Fischer Titration (KF) | Measures water content based on the quantitative reaction of iodine, sulfur dioxide, pyridine, and methanol with water. Water content is determined potentiometrically or coulometrically, with limits typically ≤0.5% (pharmaceutical standard) to prevent hydrolysis or crystallization issues. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, levels of heavy metals such as lead, cadmium, mercury, and arsenic are measured. Results must comply with ICH Q3D or pharmacopeial limits (e.g., Pb ≤ 10 ppm) to ensure product safety. |
| Chloride/Sulfate Impurities | Colorimetry or Ion Chromatography | Chloride ions are detected by silver nitrate turbidimetry; sulfate ions by barium chloride turbidimetry. Alternatively, ion chromatography may be used for quantification. Limits for inorganic anionic impurities must meet pharmaceutical standards (e.g., Cl⁻ ≤ 500 ppm). |
| Purity (Thin-Layer Chromatography, TLC) | Thin-Layer Chromatography (TLC, Supporting Method) | Silica gel plates are used with developing solvents such as ethyl acetate:n-hexane (1:1). Spots are visualized under UV light or by iodine vapor. This method provides rapid screening of major impurities and serves as a supplementary technique to HPLC, suitable for quick monitoring during manufacturing. |
| Melting Point | Capillary Melting Point Apparatus | Determine the melting range as an auxiliary purity indicator. A narrow melting range (≤2°C) indicates high purity, while a depressed or broad range suggests the presence of impurities. |
| UV-Visible Absorption Spectroscopy | UV-Vis Spectrophotometer | Dissolve the sample in ethanol or methanol and record absorption spectrum between 200–400 nm. Characteristic peaks (e.g., λmax ≈ 260–270 nm) are used for structural confirmation and rough concentration estimation (requires HPLC calibration for accuracy). |
Technical Specifications of 2-AMINO-3-FLUOROBENZONITRILE
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.5% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 72-76°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Identification (NMR) | Conforms to reference standard |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-AMINO-3-FLUOROBENZONITRILE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-AMINO-3-FLUOROBENZONITRILE
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Industrial 2-AMINO-3-FLUOROBENZONITRILE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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