N-Cbz-L-Phenylalanine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1161-13-3 |
| Product name | N-Cbz-L-Phenylalanine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Cbz-L-Phenylalanine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Cbz-L-Phenylalanine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Cbz-L-Phenylalanine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Amino-protecting group in peptide synthesis | Used as an Nα-protecting group for L-phenylalanine residues in solid-phase peptide synthesis (SPPS); amino groups are reversibly protected with benzyloxycarbonyl (Cbz) and subsequently removed via hydrogenolysis |
| Pharmaceutical Industry | Intermediate for enzyme inhibitors and antitumor agents | Serves as a key chiral building block in the synthesis of active molecules such as angiotensin-converting enzyme (ACE) inhibitors and proteasome inhibitors (e.g., bortezomib analogues) |
| Biochemical Research | Reagent for modifying proteins/peptides in structural and functional studies | Enables selective introduction of the Cbz protecting group in solution-phase or solid-phase systems to investigate amino acid side-chain reactivity, conformational stability, and enzymatic cleavage specificity |
| Organic Synthesis | Chiral auxiliary and asymmetric synthesis building block | Acts as a chiral source in asymmetric alkylation, acylation, and other reactions to construct complex natural products or pharmaceutical molecules containing a phenylalanine backbone |
Manufacturing Quality Control of N-Cbz-L-Phenylalanine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 254 nm, comparing peak area to a certified reference standard. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase, with quantification of L-isomer content relative to D-isomer and racemate. |
| Loss on Drying | Gravimetric (105 C) | Measurement of mass loss after drying under controlled temperature and time to determine volatile content including residual solvents and moisture. |
| Residual Solvents | GC-FID | Identification and quantification of common organic solvents (e.g., methanol, ethyl acetate) using gas chromatography with flame ionization detection. |
| Heavy Metals | ICP-OES | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, based on atomic emission intensity. |
| Chloride Content | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode; endpoint detected by potential change due to AgCl precipitation. |
| Sulfated Ash | Gravimetric (700 C) | Mass measurement of inorganic residue after high-temperature incineration, indicating total inorganic impurities. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light at 20 C and 589 nm to confirm stereochemical integrity and concentration. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., Z-Phe-OH, Z-Gly-Phe, des-benzyl byproducts) using gradient HPLC. |
| Water Content | Karl Fischer Titration | Coulometric or volumetric titration with iodine-based reagent to specifically quantify water via stoichiometric redox reaction. |
| Melting Point | Capillary Melting Point | Determination of temperature range at which solid transitions to liquid, indicating purity and identity based on crystalline homogeneity. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and absence testing for specified pathogens using filtration, culture media, and incubation. |
Technical Specifications of N-Cbz-L-Phenylalanine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 48.0 to 52.0°C |
| Optical Rotation | +4.0 to +6.5° (c=1, in DMF) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Cbz-L-Phenylalanine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Cbz-L-Phenylalanine
Packaging of N-Cbz-L-Phenylalanine
Industrial N-Cbz-L-Phenylalanine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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