(3S)-(+)-3-Aminopyrrolidine dihydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 116183-83-6 |
| Product name | (3S)-(+)-3-Aminopyrrolidine dihydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (3S)-(+)-3-Aminopyrrolidine dihydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (3S)-(+)-3-Aminopyrrolidine dihydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (3S)-(+)-3-Aminopyrrolidine dihydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key chiral intermediate for the antidiabetic drug sitagliptin | Serves as a chiral building block in condensation reactions with triazole derivatives to construct the DPP-4 inhibitor molecular scaffold |
| Pharmaceuticals | Synthetic raw material for antihypertensive agents (e.g., ACE inhibitors or ARBs) | Incorporated into drug molecules via amidation or alkylation reactions, leveraging its chiral aminopyrrolidine structure |
| Pharmaceuticals | Intermediate for novel antidepressants and central nervous system (CNS) drugs | Functions as a privileged scaffold in heterocyclic compound construction and functional group modification |
| Chiral Catalysis | Raw material for synthesizing chiral ligands or chiral auxiliaries | Complexed with metals via its chiral center or used as a precursor for organic small-molecule catalysts |
| Organic Synthesis | Derivatization reagent for chiral amine compounds | Applied in asymmetric synthesis or as a reference standard for chiral resolution and characterization |
Manufacturing Quality Control of (3S)-(+)-3-Aminopyrrolidine dihydrochloride
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC with UV detection | Quantification based on peak area comparison against a certified reference standard using reversed-phase chromatography. |
| Enantiomeric Purity | Chiral HPLC | Separation of (R)- and (S)-enantiomers on a chiral stationary phase, with quantification via UV response. |
| Water Content | Karl Fischer titration | Electrochemical titration where iodine reacts stoichiometrically with water in a methanol-based reagent. |
| Residual Solvents | Gas Chromatography (GC) with FID | Separation and quantification of volatile organic solvents using capillary column and flame ionization detection. |
| Heavy Metals | ICP-OES | Multi-element detection by measuring atomic emission intensities after plasma atomization and excitation. |
| Chloride Content | Potentiometric titration with silver nitrate | Titration based on formation of insoluble AgCl; endpoint detected by silver ion-selective electrode. |
| pH of Aqueous Solution | pH meter measurement | Direct potentiometric measurement of hydrogen ion activity in a 1% w/v aqueous solution. |
| Loss on Drying (LOD) | Gravimetric analysis at 105 C | Weight loss measured after drying under specified temperature and time to determine volatile content. |
| Related Substances | HPLC with UV detection | Detection and quantification of structurally related impurities using gradient reversed-phase chromatography. |
| Residue on Ignition | Gravimetric ash analysis | Mass of inorganic residue remaining after high-temperature incineration at 600–700 C. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light induced by chiral molecules in solution. |
| Microbial Contamination | Membrane filtration and colony counting | Enumeration of aerobic microorganisms following filtration, membrane transfer to agar media, and incubation. |
Technical Specifications of (3S)-(+)-3-Aminopyrrolidine dihydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow crystalline powder |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | +0.9 to +1.3 deg (c=1, H2O) |
| Melting Point | 245 to 250 °C (decomposes) |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (3S)-(+)-3-Aminopyrrolidine dihydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (3S)-(+)-3-Aminopyrrolidine dihydrochloride
Safety Information of (3S)-(+)-3-Aminopyrrolidine dihydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (3S)-(+)-3-Aminopyrrolidine dihydrochloride
Industrial (3S)-(+)-3-Aminopyrrolidine dihydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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