methyl (2R)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 116457-91-1 |
| Product name | methyl (2R)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for methyl (2R)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk methyl (2R)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of methyl (2R)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral synthetic intermediate for preparation of antiviral drugs (e.g., HIV protease inhibitors) | Produced via asymmetric synthesis or chiral resolution; used to construct amino alcohol-containing active pharmaceutical ingredients (APIs) |
| Pharmaceuticals | Precursor for neuraminidase inhibitor–based anti-influenza drugs | Serves as a chiral building block in multi-step coupling and deprotection reactions to assemble the drug molecule’s core scaffold |
| Chemical Synthesis | Chiral amino alcohol derivative for organic catalysis or ligand design | Converted into chiral ligands for asymmetric hydrogenation or addition reactions following ester hydrolysis or amine modification |
Manufacturing Quality Control of methyl (2R)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~254 nm, comparing peak area against a certified reference standard. |
| Enantiomeric Excess (ee) | Chiral HPLC | Separation of (R)- and (S)-enantiomers on a chiral stationary phase; ee calculated from peak area ratio. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, dichloromethane, toluene) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with sample moisture. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, meeting ICH Q3D limits. |
| Residual Triphenylmethanol | HPLC-UV | Specific quantification using HPLC-UV with a C18 column and gradient elution; triphenylmethanol is a common synthesis impurity. |
| Acid Value | Potentiometric Titration | Titration with standardized KOH solution to determine free carboxylic acid content, indicating hydrolysis or degradation. |
| Optical Rotation | [α]D Measurement | Polarimetric measurement at 20 °C using sodium D-line (589 nm) to confirm chiral integrity and identity. |
| Particle Size Distribution | Laser Diffraction | Dry or wet dispersion followed by light scattering analysis to assess crystallinity and handling properties. |
| Residual Palladium | ICP-OES | Quantification of Pd catalyst residue after microwave-assisted digestion, per ICH Q3D Class 1 element limits. |
| Related Substances | HPLC-UV (Forced Degradation Study) | Stability-indicating method detecting structurally related impurities (e.g., deprotected amine, ester hydrolysis products) under stressed conditions. |
| Microbial Contamination | Membrane Filtration & Plate Count | Enumeration of aerobic microorganisms and absence of specified pathogens per Ph. Eur. 5.1.4 for non-sterile APIs. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement to verify crystalline identity and purity (sharp melting range indicates high purity). |
Technical Specifications of methyl (2R)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 112–116°C |
| Optical Rotation | +28.0 to +32.0° (c=1, in CHCl3) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of methyl (2R)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of methyl (2R)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate
Safety Information of methyl (2R)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of methyl (2R)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate
Industrial methyl (2R)-3-hydroxy-2-[(triphenylmethyl)amino]propanoate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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