Di-tert-butyl N,N-diethylphosphoramidite Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 117924-33-1 |
| Product name | Di-tert-butyl N,N-diethylphosphoramidite |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Di-tert-butyl N,N-diethylphosphoramidite
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Di-tert-butyl N,N-diethylphosphoramidite Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Di-tert-butyl N,N-diethylphosphoramidite
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key phosphylating reagent for synthesizing nucleoside antiviral drugs (e.g., tenofovir) | Participates in the phosphotriester method for oligonucleotide chain assembly in solid-phase or solution-phase synthesis, delivering a protected phosphoryl group |
| Biotechnology | Phosphoramidite monomer precursor for oligonucleotide synthesis | Used in automated DNA/RNA synthesizers via phosphoramidite chemistry; activated in situ to form phosphodiester bonds with nucleosides |
| Fine Chemicals | Protecting reagent for organic phosphorus compound synthesis | Reacts with alkyl halides or alcohols under inert atmosphere to introduce a tert-butyl-protected phosphoryl moiety, followed by acid-mediated deprotection |
Manufacturing Quality Control of Di-tert-butyl N,N-diethylphosphoramidite
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | GC-FID or HPLC-UV | Quantitative determination of main component using calibrated chromatographic separation and detection. |
| Related Substances | HPLC-UV | Separation and quantification of structurally similar impurities based on retention time and peak area. |
| Residual Solvents | GC-FID with headspace sampling | Volatile organic solvents quantified by gas chromatography after thermal equilibration in sealed vials. |
| Water Content | Karl Fischer Titration | Electrochemical titration measuring water via iodine-sulfur dioxide reaction in pyridine-methanol medium. |
| Acid Value | Acid-Base Titration with NaOH | Neutralization of acidic impurities using standardized sodium hydroxide solution and potentiometric endpoint detection. |
| Phosphorus Content | ICP-OES | Quantification of total phosphorus after acid digestion by measuring characteristic atomic emission intensity. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element trace metal analysis following microwave-assisted acid digestion and isotopic mass detection. |
| Chloride Impurity | Ion Chromatography (IC) | Separation and quantification of chloride anions using conductivity detection after suppressed eluent. |
| Residue on Ignition | Gravimetric Analysis | Measurement of non-volatile inorganic residue after high-temperature ashing at 700-800 C. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against standard reference under controlled lighting. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light induced by chiral centers in solution. |
| Density | Digital Density Meter | Determination of mass per unit volume at specified temperature using oscillating U-tube principle. |
Technical Specifications of Di-tert-butyl N,N-diethylphosphoramidite
| Test Item | Specification |
|---|---|
| Appearance | Colorless liquid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Refractive Index (n20/D) | 1.430–1.450 |
| Odor | Characteristic, mild phosphorous odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Di-tert-butyl N,N-diethylphosphoramidite
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Di-tert-butyl N,N-diethylphosphoramidite
Safety Information of Di-tert-butyl N,N-diethylphosphoramidite
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Di-tert-butyl N,N-diethylphosphoramidite
Industrial Di-tert-butyl N,N-diethylphosphoramidite Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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