Benzyl (R)-5-oxotetrahydrofuran-3-ylcarbamate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 118399-28-3 |
| Product name | Benzyl (R)-5-oxotetrahydrofuran-3-ylcarbamate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Benzyl (R)-5-oxotetrahydrofuran-3-ylcarbamate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Benzyl (R)-5-oxotetrahydrofuran-3-ylcarbamate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Benzyl (R)-5-oxotetrahydrofuran-3-ylcarbamate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Synthesis | Used as a chiral intermediate in the synthesis of antiviral or targeted therapy drugs | Chiral center construction via asymmetric catalytic hydrogenation or enzymatic reaction, followed by carbamate derivatization |
| Biopharmaceuticals | Used as a protecting group or structural motif in peptide-based drug synthesis | Selective protection and coupling enabled by the benzyloxycarbonyl (Cbz) amino group, implemented through solid-phase or multi-step synthesis strategies |
| High-End Fine Chemicals | Serves as a starting material for synthesizing novel functional molecules | Complex molecular architectures built via selective functional group transformations—such as reduction, cyclization, and substitution |
Manufacturing Quality Control of Benzyl (R)-5-oxotetrahydrofuran-3-ylcarbamate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~210–230 nm, comparing peak area against a certified reference standard. |
| Chiral Purity (Enantiomeric Excess) | Chiral HPLC | Separation of (R)- and (S)-enantiomers on a chiral stationary phase (e.g., Chiralpak AD-H, OD-H), with UV detection and calculation of ee from peak areas. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection, quantifying common solvents (e.g., methanol, ethyl acetate, toluene) against internal/external standards per ICH Q3C. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration based on the reaction of iodine with water in anhydrous pyridine/methanol medium; coulometric mode provides high sensitivity for low water levels. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification (e.g., Pb, Cd, Hg, As) after acid digestion, using isotopic dilution or external calibration for compliance with ICH Q3D. |
| Residual Palladium | ICP-MS | Specific quantification of Pd residues (common from asymmetric hydrogenation catalysts) following microwave-assisted acid digestion and matrix-matched calibration. |
| Related Substances | HPLC-UV (Forced Degradation Compatible) | Gradient HPLC-UV method validated for specificity, detecting structurally related impurities (e.g., hydrolysis/decarboxylation products, diastereomers) under stressed conditions. |
| Optical Rotation | [α]D Measurement | Direct measurement of specific optical rotation at 20 °C using sodium D-line (589 nm) in specified solvent (e.g., CHCl₃), confirming chiral identity and batch consistency. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition determination via controlled heating; sharp melting range confirms crystallinity and absence of significant eutectic impurities. |
| Appearance & Color | Visual Inspection / APHA Color Scale | Subjective visual assessment against water or platinum-cobalt standards for clarity, color, and particulate matter per USP <911>. |
Technical Specifications of Benzyl (R)-5-oxotetrahydrofuran-3-ylcarbamate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (LC-MS) |
| Optical Rotation | +53.0 to +57.0° (c=1, in CHCl3) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 85.0 to 89.0°C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Benzyl (R)-5-oxotetrahydrofuran-3-ylcarbamate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Benzyl (R)-5-oxotetrahydrofuran-3-ylcarbamate
Safety Information of Benzyl (R)-5-oxotetrahydrofuran-3-ylcarbamate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Benzyl (R)-5-oxotetrahydrofuran-3-ylcarbamate
Industrial Benzyl (R)-5-oxotetrahydrofuran-3-ylcarbamate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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