4-Methylumbelliferone Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 90-33-5 |
| Product name | 4-Methylumbelliferone |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeReagent GradeCosmetic GradeFood Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Methylumbelliferone
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Methylumbelliferone Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Methylumbelliferone
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Treatment of biliary disorders | Synthesized as a pharmaceutical intermediate |
| Cosmetics | Fragrance additive | Formulation compounding |
| Fine fragrances | Synthesis of coumarin-based fragrances | Chemical synthesis |
| Agriculture | Insecticide intermediate | Chemical synthesis and formulation processing |
| Research | Laboratory reagent | Analytical method development |
Manufacturing Quality Control of 4-Methylumbelliferone
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~310 nm, based on peak area comparison against a certified reference standard. |
| Loss on Drying (LOD) | Gravimetric (105 °C, 2 h) | Mass loss measured after drying under specified temperature and time; reflects volatile impurities and residual solvents. |
| Residue on Ignition (Sulfated Ash) | Gravimetric (500–600 °C) | Mass of inorganic residue remaining after high-temperature combustion of organic matrix and sulfuric acid treatment. |
| Heavy Metals (as Pb) | Colorimetric (Thioacetamide, USP <231>) | Formation of colored metal sulfide complexes under controlled pH; compared visually or spectrophotometrically to lead standard. |
| Chloride Impurity | Ion Chromatography (IC) or Potentiometric Titration | Separation and quantification of chloride ions via IC conductivity detection, or argentometric titration with AgNO₃ endpoint detection. |
| Related Substances | HPLC-DAD or HPLC-MS | Separation and identification/quantification of structurally similar impurities using gradient HPLC with diode-array or mass spectrometric detection. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed as solid-to-liquid phase change; used for identity confirmation and purity assessment (sharp range indicates high purity). |
| Specific Optical Rotation | [α]D | Measurement of rotation of plane-polarized light at 589 nm; confirms chiral integrity and absence of racemization (though hydroxymethylcoumarin is achiral, this test may be included for batch consistency per monograph). |
| Solvent Residues (e.g., Ethanol, Acetone) | GC-FID | Headspace or direct-injection GC with flame ionization detection to quantify residual process solvents per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration quantifying water via iodine generation and stoichiometric reaction with water in anhydrous medium. |
| pH of Aqueous Suspension (1% w/v) | pH Meter | Measurement of hydrogen ion activity in a saturated aqueous suspension; indicates acidic/basic degradation products or residual reagents. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity to determine volumetric particle size distribution in dispersed solid sample. |
| Microbial Limits | Membrane Filtration + Culture | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per pharmacopoeial methods (USP <61>, <62>). |
Technical Specifications of 4-Methylumbelliferone
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 192–195°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Methylumbelliferone
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Methylumbelliferone
Packaging of 4-Methylumbelliferone
Industrial 4-Methylumbelliferone Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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